Synonyms: Mixture Azure I and Methylene Blue
CAS No.: 37247-10-2
Molecular Weight: 625.73
Chemical Formula: C16H18N3S . C15H16N3S . 2Cl
Product Codes: B649
Ingredient CAS No Percent Hazardous --------------------------------------- ------------ ------------ --------- Azure II 37247-10-2 90 - 100% Yes
Emergency Overview
--------------------------
WARNING! TOXICOLOGICAL PROPERTIES UNKNOWN. HARMFUL IF SWALLOWED. MAY BE HARMFUL IF INHALED. MAY CAUSE IRRITATION TO SKIN, EYES, AND RESPIRATORY TRACT.
Potential Health Effects
----------------------------------
Information on the human health effects from exposure to this substance is limited.
Inhalation:
No information found, but compound should be handled as a potential health hazard. May cause irritation to the respiratory tract. Symptoms may include coughing, sore throat, labored breathing, and chest pain.
Ingestion:
For Methylene Blue Component: A burning sensation of the mouth may be noted following ingestion of methylene blue. May cause nausea, vomiting, diarrhea, and gastritis. Large doses may cause abdominal and chest pain, headache, profuse sweating, mental confusion, painful micturation, and methemoglobinemia.
For Azure I component: No information found, but compound should be handled as a potential health hazard. May cause irritation to the gastrointestinal tract. Symptoms may include nausea, vomiting and diarrhea.
Skin Contact:
For Methylene Blue Component: Not expected to be a health hazard from skin exposure. Methylene blue may color the skin a bluish color. May cause photosensitization. For Azure I component: No information found, but compound should be handled as a potential health hazard. May cause irritation with redness and pain.
Eye Contact:
No information found, but compound should be handled as a potential health hazard. May cause irritation, redness and pain.
Chronic Exposure:
No information found.
Aggravation of Pre-existing Conditions:
No information found.
Inhalation:
Remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention.
Ingestion:
Induce vomiting immediately as directed by medical personnel. Never give anything by mouth to an unconscious person. Get medical attention.
Skin Contact:
Immediately flush skin with plenty of water for at least 15 minutes. Remove contaminated clothing and shoes. Get medical attention. Wash clothing before reuse. Thoroughly clean shoes before reuse.
Eye Contact:
Immediately flush eyes with plenty of water for at least 15 minutes, lifting lower and upper eyelids occasionally. Get medical attention immediately.
Fire:
Not expected to be a fire hazard.
Explosion:
No information found.
Fire Extinguishing Media:
Water spray, dry chemical, alcohol foam, or carbon dioxide.
Special Information:
In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full facepiece operated in the pressure demand or other positive pressure mode.
Ventilate area of leak or spill. Keep unnecessary and unprotected people away from area of spill. Wear appropriate personal protective equipment as specified in Section 8. Spills: Pick up and place in a suitable container for reclamation or disposal, using a method that does not generate dust.
Keep in a tightly closed container, stored in a cool, dry, ventilated area. Protect against physical damage. Containers of this material may be hazardous when empty since they retain product residues (dust, solids); observe all warnings and precautions listed for the product.
Airborne Exposure Limits:
None established.
Ventilation System:
A system of local and/or general exhaust is recommended to keep employee exposures as low as possible. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area. Please refer to the ACGIH document, Industrial Ventilation, A Manual of Recommended Practices, most recent edition, for details.
Personal Respirators (NIOSH Approved):
For conditions of use where exposure to the dust or mist is apparent, a half-face dust/mist respirator may be worn. For emergencies or instances where the exposure levels are not known, use a full-face positive-pressure, air-supplied respirator. WARNING: Air-purifying respirators do not protect workers in oxygen-deficient atmospheres.
Skin Protection:
Wear impervious protective clothing, including boots, gloves, lab coat, apron or coveralls, as appropriate, to prevent skin contact.
Eye Protection:
Use chemical safety goggles and/or a full face shield where splashing is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures:
There is insufficient data in the published literature to assign complete numerical SAF-T-DATA* ratings and laboratory protective equipment for this product. Special precautions must be used in storage, use and handling. Protective equipment for laboratory bench use should be chosen using professional judgment based on the size and type of reaction or test to be conducted and the available ventilation, with overriding consideration to minimize contact with the chemical.
Appearance:
Red to brown powder.
Odor:
No information found.
Solubility:
Slight (0.1-1%)
Specific Gravity:
No information found.
pH:
No information found.
% Volatiles by volume @ 21C (70F):
0
Boiling Point:
No information found.
Melting Point:
185C (365F)
Vapor Density (Air=1):
No information found.
Vapor Pressure (mm Hg):
No information found.
Evaporation Rate (BuAc=1):
No information found.
Stability:
Stable under ordinary conditions of use and storage.
Hazardous Decomposition Products:
Hydrogen chloride, and oxides of carbon, sulfur and nitrogen may be formed when heated to decomposition.
Hazardous Polymerization:
Will not occur.
Incompatibilities:
Strong oxidizing agents, alkali, dichromates, alkali iodides, reducing agents.
Conditions to Avoid:
Incompatibles.
For Azure II (mixture): No LD50/LC50 information found relating to normal routes of occupational exposure.
For Methylene Blue Component: Methylene blue: Oral rat LD50: 1180 mg/kg Investigated as a mutagen, reproductive effector.
For Azure I component:\Por Azure I component: No LD50/LC50 information found relating to normal routes of occupational exposure. Investigated as a mutagen.
--------\Cancer Lists\------------------------------------------------------
---NTP Carcinogen---
Ingredient Known Anticipated IARC Category
------------------------------------ ----- ----------- -------------
Azure II (37247-10-2) No No None
Environmental Fate:
For Methylene Blue Component: When released into the soil, this material is not expected to evaporate significantly. When released into water, this material is not expected to evaporate significantly. This material has an estimated bioconcentration factor (BCF) of less than 100. This material is not expected to significantly bioaccumulate.
Environmental Toxicity:
No information found.
Whatever cannot be saved for recovery or recycling should be managed in an appropriate and approved waste disposal facility. Processing, use or contamination of this product may change the waste management options. State and local disposal regulations may differ from federal disposal regulations. Dispose of container and unused contents in accordance with federal, state and local requirements.
Not regulated.
--------\Chemical Inventory Status - Part 1\---------------------------------
Ingredient TSCA EC Japan Australia
----------------------------------------------- ---- --- ----- ---------
Azure II (37247-10-2) Exempt No No Yes
--------\Chemical Inventory Status - Part 2\---------------------------------
--Canada--
Ingredient Korea DSL NDSL Phil.
----------------------------------------------- ----- --- ---- -----
Azure II (37247-10-2) No No No No
--------\Federal, State & International Regulations - Part 1\----------------
-SARA 302- ------SARA 313------
Ingredient RQ TPQ List Chemical Catg.
----------------------------------------- --- ----- ---- --------------
Azure II (37247-10-2) No No No No
--------\Federal, State & International Regulations - Part 2\----------------
-RCRA- -TSCA-
Ingredient CERCLA 261.33 8(d)
----------------------------------------- ------ ------ ------
Azure II (37247-10-2) No No No
Chemical Weapons Convention: No TSCA 12(b): No CDTA: No
SARA 311/312: Acute: Yes Chronic: No Fire: No Pressure: No
Reactivity: No (Pure / Solid)
Australian Hazchem Code: None allocated.
Poison Schedule: None allocated.
WHMIS:
This MSDS has been prepared according to the hazard criteria of the Controlled Products Regulations (CPR) and the MSDS contains all of the information required by the CPR.
Label Hazard Warning:
WARNING! TOXICOLOGICAL PROPERTIES UNKNOWN. HARMFUL IF SWALLOWED. MAY BE HARMFUL IF INHALED. MAY CAUSE IRRITATION TO SKIN, EYES, AND RESPIRATORY TRACT.
Label Precautions:
No SAF-T-DATA Ratings have been developed for this product. Read and follow all warnings, precautions, instructions and other safety and handling information on the label and MSDS.
Avoid contact with eyes, skin and clothing.
Avoid breathing dust.
Keep container closed.
Use with adequate ventilation.
Wash thoroughly after handling.
INTENDED FOR R & D USE ONLY.
NOT ON THE TSCA INVENTORY.
Label First Aid:
In case of contact, immediately flush eyes or skin with plenty of water for at least 15 minutes. Remove contaminated clothing and shoes. Wash clothing before reuse. If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. If swallowed, induce vomiting immediately as directed by medical personnel. Never give anything by mouth to an unconscious person. In all cases, get medical attention.
Product Use:
Research and Development Use Only. Note: Chemical substances that are manufactured or imported in small quantities solely for the use in Research & Development are not subject to the notification requirements of the Toxic Substances Control Act (TSCA), 15 USC 2604 (h) et seq. Reference - 40 CFR 720.36 These products are not on the TSCA Inventory. They are used only in Research and Development.
Revision Information:
MSDS Section(s) changed since last revision of document include: 1, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 15, 16.
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Prepared by: Environmental Health & Safety
Phone Number: (314) 654-1600 (U.S.A.)