Benzene for HPLC MSDS
Section 1: Chemical Product and Company Identification
Product Name: Benzene For HPLC
Catalog Codes: SLB1564, SLB3055, SLB2881
CAS#: 71-43-2
RTECS: CY1400000
TSCA: TSCA 8(b) inventory: Benzene
CI#: Not available.
Synonym: Benzol; Benzine
Chemical Name: Benzene
Chemical Formula: C6-H6
Section 2: Composition and Information on Ingredients
Composition:
Name CAS # % by Weight
Benzene 71-43-2 100
Toxicological Data on Ingredients: Benzene: ORAL (LD50): Acute: 930 mg/kg [Rat]. 4700 mg/kg [Mouse]. DERMAL (LD50):
Acute: >9400 mg/kg [Rabbit]. VAPOR (LC50): Acute: 10000 ppm 7 hours [Rat].
Section 3: Hazards Identification
Potential Acute Health Effects:
Very hazardous in case of eye contact (irritant), of inhalation. Hazardous in case of skin contact (irritant, permeator), of ingestion. Inflammation of the eye is characterized by redness, watering, and itching.
Potential Chronic Health Effects:
CARCINOGENIC EFFECTS: Classified A1 (Confirmed for human.) by ACGIH, 1 (Proven for human.) by IARC.
MUTAGENIC EFFECTS: Classified POSSIBLE for human. Mutagenic for mammalian somatic cells. Mutagenic for bacteria and/or yeast.
TERATOGENIC EFFECTS: Not available.
DEVELOPMENTAL TOXICITY: Classified Reproductive system/toxin/female [POSSIBLE].
The substance is toxic to blood, bone marrow, central nervous system (CNS).
The substance may be toxic to liver, Urinary System.
Repeated or prolonged exposure to the substance can produce target organs damage.
Section 4: First Aid Measures
Eye Contact:
Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Cold water may be used. WARM water MUST be used. Get medical attention immediately.
Skin Contact:
In case of contact, immediately flush skin with plenty of water. Cover the irritated skin with an emollient. Remove contaminated clothing and shoes. Wash clothing before reuse. Thoroughly clean shoes before reuse. Get medical attention.
Serious Skin Contact:
Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek immediate medical attention.
Inhalation:
If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention if symptoms appear.
Serious Inhalation:
Evacuate the victim to a safe area as soon as possible. Loosen tight clothing such as a collar, tie, belt or waistband. If breathing is difficult, administer oxygen. If the victim is not breathing, perform mouth-to-mouth resuscitation. Seek medical attention.
Ingestion:
Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. If large quantities of this material are swallowed, call a physician immediately. Loosen tight clothing such as a collar, tie, belt or waistband.
Serious Ingestion: Not available.
Section 5: Fire and Explosion Data
Flammability of the Product: Flammable.
Auto-Ignition Temperature: 497.78°C (928°F)
Flash Points: CLOSED CUP: -11.1°C (12°F). (Setaflash)
Flammable Limits: LOWER: 1.2% UPPER: 7.8%
Products of Combustion: These products are carbon oxides (CO, CO2).
Fire Hazards in Presence of Various Substances:
Highly flammable in presence of open flames and sparks, of heat.
Slightly flammable to flammable in presence of oxidizing materials.
Non-flammable in presence of shocks.
Explosion Hazards in Presence of Various Substances:
Risks of explosion of the product in presence of mechanical impact: Not available.
Risks of explosion of the product in presence of static discharge: Not available.
Explosive in presence of oxidizing materials, of acids.
Fire Fighting Media and Instructions:
Flammable liquid, soluble or dispersed in water.
SMALL FIRE: Use DRY chemical powder.
LARGE FIRE: Use alcohol foam, water spray or fog.
Special Remarks on Fire Hazards:
Extremely flammable liquid and vapor. Vapor may cause flash fire.
Reacts on contact with iodine heptafluoride gas.
Dioxygenyl tetrafluoroborate is as very powferful oxidant. The addition of a small particle to small samples of benzene, at ambient temperature, causes ignition. Contact with sodium peroxide with benzene causes ignition. Benzene ignites in contact with powdered chromic anhydride. Virgorous or incandescent reaction with hydrogen + Raney nickel (above 210 C) and bromine trifluoride.
Special Remarks on Explosion Hazards:
Benzene vapors + chlorine and light causes explosion.
Reacts explosively with bromine pentafluoride, chlorine, chlorine trifluoride, diborane, nitric acid, nitryl perchlorate, liquid oxygen, ozone, silver perchlorate. Benzene + pentafluoride and methoxide (from arsenic pentafluoride and potassium methoxide) in trichlorotrifluoroethane causes explosion. Interaction of nitryl perchlorate with benzene gave a slight explosion and flash. The solution of permanganic acid ( or its explosive anhydride, dimaganese heptoxide) produced by interaction of permanganates and sulfuric acid will explode on contact with benzene. Peroxodisulfuric acid is a very powferful oxidant. Uncontrolled contact with benzene may cause explosion. Mixtures of peroxomonsulfuric acid with benzene explodes.
Section 6: Accidental Release Measures
Small Spill: Absorb with an inert material and put the spilled material in an appropriate waste disposal.
Large Spill:
Flammable liquid.
Keep away from heat. Keep away from sources of ignition. Stop leak if without risk. Absorb with DRY earth, sand or other non-combustible material. Do not touch spilled material. Prevent entry into sewers, basements or confined areas; dike if needed. Be careful that the product is not present at a concentration level above TLV. Check TLV on the MSDS and with local authorities.
Section 7: Handling and Storage
Precautions:
Keep locked up.. Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do not ingest. Do not breathe gas/fumes/ vapor/spray. In case of insufficient ventilation, wear suitable respiratory equipment. If ingested, seek medical advice immediately and show the container or the label. Avoid contact with skin and eyes. Keep away from incompatibles such as oxidizing agents, acids.
Storage:
Store in a segregated and approved area. Keep container in a cool, well-ventilated area. Keep container tightly closed and sealed until ready for use. Avoid all possible sources of ignition (spark or flame).
Section 8: Exposure Controls/Personal Protection
Engineering Controls:
Provide exhaust ventilation or other engineering controls to keep the airborne concentrations of vapors below their respective threshold limit value. Ensure that eyewash stations and safety showers are proximal to the work-station location.
Personal Protection:
Splash goggles. Lab coat. Vapor respirator. Be sure to use an approved/certified respirator or equivalent.
Gloves.
Personal Protection in Case of a Large Spill:
Splash goggles. Full suit. Vapor respirator. Boots. Gloves. A self contained breathing apparatus should be used to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this product.
Exposure Limits:
TWA: 0.5 STEL: 2.5 (ppm) from ACGIH (TLV) [United States]
TWA: 1.6 STEL: 8 (mg/m3) from ACGIH (TLV) [United States]
TWA: 0.1 STEL: 1 from NIOSH
TWA: 1 STEL: 5 (ppm) from OSHA (PEL) [United States]
TWA: 10 (ppm) from OSHA (PEL) [United States]
TWA: 3 (ppm) [United Kingdom (UK)]
TWA: 1.6 (mg/m3) [United Kingdom (UK)]
TWA: 1 (ppm) [Canada]
TWA: 3.2 (mg/m3) [Canada]
TWA: 0.5 (ppm) [Canada]Consult local authorities for acceptable exposure limits.
Section 9: Physical and Chemical Properties
Physical state and appearance: Liquid.
Odor:
Aromatic. Gasoline-like, rather pleasant.
(Strong.)
Taste: Not available.
Molecular Weight: 78.11 g/mole
Color: Clear Colorless. Colorless to light yellow.
pH (1% soln/water): Not available.
Boiling Point: 80.1 (176.2°F)
Melting Point: 5.5°C (41.9°F)
Critical Temperature: 288.9°C (552°F)
Specific Gravity: 0.8787 @ 15 C (Water = 1)
Vapor Pressure: 10 kPa (@ 20°C)
Vapor Density: 2.8 (Air = 1)
Volatility: Not available.
Odor Threshold: 4.68 ppm
Water/Oil Dist. Coeff.: The product is more soluble in oil; log(oil/water) = 2.1
Ionicity (in Water): Not available.
Dispersion Properties: See solubility in water, diethyl ether, acetone.
Solubility:
Miscible in alcohol, chloroform, carbon disulfide oils, carbon tetrachloride, glacial acetic acid, diethyl ether,
acetone.
Very slightly soluble in cold water.
Section 10: Stability and Reactivity Data
Stability: The product is stable.
Instability Temperature: Not available.
Conditions of Instability: Heat, ignition sources, incompatibles.
Incompatibility with various substances: Highly reactive with oxidizing agents, acids.
Corrosivity: Non-corrosive in presence of glass.
Special Remarks on Reactivity:
Benzene vapors + chlorine and light causes explosion.
Reacts explosively with bromine pentafluoride, chlorine, chlorine trifluoride, diborane, nitric acid, nitryl perchlorate, liquid oxygen, ozone, silver perchlorate. Benzene + pentafluoride and methoxide (from arsenic pentafluoride and potassium methoxide) in trichlorotrifluoroethane causes explosion. Interaction of nitryl perchlorate with benzene gave a slight explosion and flash.
The solution of permanganic acid ( or its explosive anhydride, dimaganese heptoxide) produced by interaction of permanganates and sulfuric acid will explode on contact with benzene.
Peroxodisulfuric acid is a very powferful oxidant. Uncontrolled contact with benzene may cause explosion. Mixtures of peroxomonsulfuric acid with benzene explodes.
Special Remarks on Corrosivity: Not available.
Polymerization: Will not occur.
Section 11: Toxicological Information
Routes of Entry: Absorbed through skin. Dermal contact. Eye contact. Inhalation.
Toxicity to Animals:
WARNING: THE LC50 VALUES HEREUNDER ARE ESTIMATED ON THE BASIS OF A 4-HOUR EXPOSURE.
Acute oral toxicity (LD50): 930 mg/kg [Rat].
Acute dermal toxicity (LD50): >9400 mg/kg [Rabbit].
Acute toxicity of the vapor (LC50): 10000 7 hours [Rat].
Chronic Effects on Humans:
CARCINOGENIC EFFECTS: Classified A1 (Confirmed for human.) by ACGIH, 1 (Proven for human.) by IARC.
MUTAGENIC EFFECTS: Classified POSSIBLE for human. Mutagenic for mammalian somatic cells. Mutagenic for bacteria and/or yeast.
DEVELOPMENTAL TOXICITY: Classified Reproductive system/toxin/female [POSSIBLE].
Causes damage to the following organs: blood, bone marrow, central nervous system (CNS).
May cause damage to the following organs: liver, Urinary System.
Other Toxic Effects on Humans:
Very hazardous in case of inhalation.
Hazardous in case of skin contact (irritant, permeator), of ingestion.
Special Remarks on Toxicity to Animals: Not available.
Special Remarks on Chronic Effects on Humans:
May cause adverse reproductive effects (female fertility, Embryotoxic and/or foetotoxic in animal) and birth defects. May affect genetic material (mutagenic).
May cause cancer (tumorigenic, leukemia))
Human: passes the placental barrier, detected in maternal milk.
Special Remarks on other Toxic Effects on Humans:
Acute Potential Health Effects:
Skin: Causes skin irritation. It can be absorbed through intact skin and affect the liver, blood, metabolism,and urinary system.
Eyes: Causes eye irritation.
Inhalation: Causes respiratory tract and mucous membrane irritation. Can be absorbed through the lungs. May affect behavior/Central and Peripheral nervous systems (somnolence, muscle weakness, general anesthetic, and other symptoms similar to ingestion), gastrointestinal tract (nausea), blood metabolism, urinary system.
Ingestion: May be harmful if swallowed. May cause gastrointestinal tract irritation including vomiting. May affect behavior/Central and Peripheral nervous systems (convulsions, seizures, tremor, irritability, initial CNS stimulation followed by depression, loss of coordination, dizziness, headache, weakness, pallor, flushing), respiration (breathlessness and chest constriction), cardiovascular system, (shallow/rapid pulse), and blood.
Section 12: Ecological Information
Ecotoxicity: Not available.
BOD5 and COD: Not available.
Products of Biodegradation:
Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise.
Toxicity of the Products of Biodegradation: The products of degradation are less toxic than the product itself.
Special Remarks on the Products of Biodegradation: Not available.
Section 13: Disposal Considerations
Waste Disposal:
Waste must be disposed of in accordance with federal, state and local environmental
control regulations.
Section 14: Transport Information
DOT Classification: CLASS 3: Flammable liquid.
Identification: : Benzene UNNA: 1114 PG: II
Special Provisions for Transport: Not available.
Section 15: Other Regulatory Information
Federal and State Regulations:
California prop. 65: This product contains the following ingredients for which the State of California has found to
cause cancer, birth defects or other reproductive harm, which would require a warning under the statute: Benzene
California prop. 65 (no significant risk level): Benzene: 0.007 mg/day (value)
California prop. 65: This product contains the following ingredients for which the State of California has found to
cause cancer which would require a warning under the statute: Benzene
Connecticut carcinogen reporting list.: Benzene
Connecticut hazardous material survey.: Benzene
Illinois toxic substances disclosure to employee act: Benzene
Illinois chemical safety act: Benzene
New York release reporting list: Benzene
Rhode Island RTK hazardous substances: Benzene
Pennsylvania RTK: Benzene
Minnesota: Benzene
Michigan critical material: Benzene
Massachusetts RTK: Benzene
Massachusetts spill list: Benzene
New Jersey: Benzene
New Jersey spill list: Benzene
Louisiana spill reporting: Benzene
California Director's list of Hazardous Substances: Benzene
TSCA 8(b) inventory: Benzene
SARA 313 toxic chemical notification and release reporting: Benzene
CERCLA: Hazardous substances.: Benzene: 10 lbs. (4.536 kg)
Other Regulations:
OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200).
EINECS: This product is on the European Inventory of Existing Commercial Chemical Substances.
Other Classifications:
WHMIS (Canada):
CLASS B-2: Flammable liquid with a flash point lower than 37.8°C (100°F).
CLASS D-2A: Material causing other toxic effects (VERY TOXIC).
DSCL (EEC):
R11- Highly flammable.
R22- Harmful if swallowed.
R38- Irritating to skin.
R41- Risk of serious damage to eyes.
R45- May cause cancer.
R62- Possible risk of impaired fertility.
S2- Keep out of the reach of children.
S26- In case of contact with eyes, rinse
immediately with plenty of water and seek
medical advice.
S39- Wear eye/face protection.
S46- If swallowed, seek medical advice
immediately and show this container or label.
S53- Avoid exposure - obtain special
instructions before use.
HMIS (U.S.A.):
Health Hazard: 2
Fire Hazard: 3
Reactivity: 0
Personal Protection: h
National Fire Protection Association (U.S.A.):
Health: 2
Flammability: 3
Reactivity: 0
Specific hazard:
Protective Equipment:
Gloves.
Lab coat.
Vapor respirator. Be sure to use an
approved/certified respirator or
equivalent. Wear appropriate respirator
when ventilation is inadequate.
Splash goggles.
Section 16: Other Information
References: Not available.
Other Special Considerations: Not available.
Created: 10/10/2005 08:35 PM
Last Updated: 11/06/2008 12:00 PM