Synonyms: Azabenzene
CAS No.: 110-86-1
Molecular Weight: 79.10
Chemical Formula: C5H5N
Product Codes:
J.T. Baker: 3348, 9105, 9393
Mallinckrodt: 7180, 7181
Ingredient CAS No Percent Hazardous --------------------------------------- ------------ ------------ --------- Pyridine 110-86-1 99 - 100% Yes
Emergency Overview
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WARNING! FLAMMABLE LIQUID AND VAPOR. HARMFUL IF SWALLOWED, INHALED OR ABSORBED THROUGH SKIN. AFFECTS CENTRAL NERVOUS SYSTEM, LIVER AND KIDNEYS. CAUSES SEVERE IRRITATION TO EYES, SKIN AND RESPIRATORY TRACT.
SAF-T-DATA(tm) Ratings (Provided here for your convenience)
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Health Rating: 3 - Severe (Life)
Flammability Rating: 2 - Moderate
Reactivity Rating: 2 - Moderate
Contact Rating: 3 - Severe
Lab Protective Equip: GOGGLES & SHIELD; LAB COAT & APRON; VENT HOOD; PROPER GLOVES; CLASS B EXTINGUISHER
Storage Color Code: Red (Flammable)
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Potential Health Effects
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Inhalation:
Inhalation causes severe irritation to the respiratory tract. Symptoms of overexposure include headache, dizziness, nausea, shortness of breath, coughing, insomnia, diarrhea, gastrointestinal disturbances, and back pain with urinary frequency. Liver and kidney damage may occur. May be fatal.
Ingestion:
Toxic effects parallel those of inhalation. May be fatal if swallowed.
Skin Contact:
Causes severe irritation, possibly burns, to the skin. Symptoms include redness and severe pain. Absorption through the skin may occur, resulting in toxic effects similar to inhalation. May act as a photosensitizer.
Eye Contact:
Vapors cause eye irritation. Splashes cause severe irritation, possible corneal burns and eye damage.
Chronic Exposure:
Liver and kidney damage has been reported.
Aggravation of Pre-existing Conditions:
Persons with pre-existing skin, eye or central nervous system disorders, or impaired liver, kidney, or pulmonary function may be more susceptible to the effects of this substance.
Inhalation:
Remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention immediately.
Ingestion:
If swallowed, give large quantities of water to drink and get medical attention immediately. Never give anything by mouth to an unconscious person.
Skin Contact:
Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Get medical attention immediately. Wash clothing before reuse. Thoroughly clean shoes before reuse.
Eye Contact:
Immediately flush eyes with plenty of water for at least 15 minutes, lifting lower and upper eyelids occasionally. Get medical attention immediately.
Fire:
Flash point: 20C (68F) CC
Autoignition temperature: 482C (900F)
Flammable limits in air % by volume:
lel: 1.8; uel: 12.4
Flammable Liquid Contact with strong oxidizers may cause fire.
Explosion:
Above flash point, vapor-air mixtures are explosive within flammable limits noted above. Vapors can flow along surfaces to distant ignition source and flash back. Sensitive to static discharge.
Fire Extinguishing Media:
Dry chemical, foam or carbon dioxide. Water spray may be used to keep fire exposed containers cool. Water may be ineffective.
Special Information:
In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full facepiece operated in the pressure demand or other positive pressure mode. Water may be used to flush spills away from exposures and to dilute spills to non-flammable mixtures.
Ventilate area of leak or spill. Remove all sources of ignition. Wear appropriate personal protective equipment as specified in Section 8. Isolate hazard area. Keep unnecessary and unprotected personnel from entering. Contain and recover liquid when possible. Use non-sparking tools and equipment. Collect liquid in an appropriate container or absorb with an inert material (e. g., vermiculite, dry sand, earth), and place in a chemical waste container. Do not use combustible materials, such as saw dust. Do not flush to sewer! If a leak or spill has not ignited, use water spray to disperse the vapors, to protect personnel attempting to stop leak, and to flush spills away from exposures. US Regulations (CERCLA) require reporting spills and releases to soil, water and air in excess of reportable quantities. The toll free number for the US Coast Guard National Response Center is (800) 424-8802.
J. T. Baker SOLUSORB® solvent adsorbent is recommended for spills of this product.
Protect against physical damage. Store in a cool, dry well-ventilated location, away from any area where the fire hazard may be acute. Outside or detached storage is preferred. Separate from incompatibles. Containers should be bonded and grounded for transfers to avoid static sparks. Storage and use areas should be No Smoking areas. Use non-sparking type tools and equipment, including explosion proof ventilation. Containers of this material may be hazardous when empty since they retain product residues (vapors, liquid); observe all warnings and precautions listed for the product. Do Not attempt to clean empty containers since residue is difficult to remove. Do not pressurize, cut, weld, braze, solder, drill, grind or expose such containers to heat, sparks, flame, static electricity or other sources of ignition: they may explode and cause injury or death.
Airborne Exposure Limits:
For Pyridine:
- OSHA Permissible Exposure Limit (PEL) -
5 ppm (TWA).
- ACGIH Threshold Limit Value (TLV) -
1 ppm (TWA), A3 - Confirmed animal carcinogen with unknown relevance to humans
- NIOSH Recommended Exposure Limit (REL) -
5 ppm (Ceiling).
Ventilation System:
A system of local and/or general exhaust is recommended to keep employee exposures below the Airborne Exposure Limits. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area. Please refer to the ACGIH document, Industrial Ventilation, A Manual of Recommended Practices, most recent edition, for details.
Personal Respirators (NIOSH Approved):
If the exposure limit is exceeded and engineering controls are not feasible, a full facepiece respirator with organic vapor cartridge may be worn up to 50 times the exposure limit or the maximum use concentration specified by the appropriate regulatory agency or respirator supplier, whichever is lowest. For emergencies or instances where the exposure levels are not known, use a full-facepiece positive-pressure, air-supplied respirator. WARNING: Air purifying respirators do not protect workers in oxygen-deficient atmospheres. Where respirators are required, you must have a written program covering the basic requirements in the OSHA respirator standard. These include training, fit testing, medical approval, cleaning, maintenance, cartridge change schedules, etc. See 29CFR1910.134 for details.
Skin Protection:
Wear impervious protective clothing, including boots, gloves, lab coat, apron or coveralls, as appropriate, to prevent skin contact.
Eye Protection:
Use chemical safety goggles and/or a full face shield where splashing is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Appearance:
Colorless to yellow liquid.
Odor:
Penetrating, sickening.
Solubility:
Miscible in water.
Specific Gravity:
0.98 @ 25C/4C
pH:
8.5
% Volatiles by volume @ 21C (70F):
100
Boiling Point:
115.3C (239F)
Melting Point:
-42C (-44F)
Vapor Density (Air=1):
2.72
Vapor Pressure (mm Hg):
18 @ 20C (68F)
Evaporation Rate (BuAc=1):
No information found.
Stability:
Stable under ordinary conditions of use and storage. Heat will contribute to instability.
Hazardous Decomposition Products:
May form cyanide fumes and oxides of carbon and nitrogen if heated to decomposition.
Hazardous Polymerization:
Will not occur.
Incompatibilities:
Heat, flame, maleic anhydride, perchromates, strong acids, strong oxidizers. Will attack some forms of plastics, rubber, and coatings.
Conditions to Avoid:
Heat, flames, ignition sources and incompatibles.
Oral rat LD50: 891 mg/kg; inhalation rat LC50: 28500 mg/m3/1-hour; skin rabbit LD50: 1121 mg/kg; Irritation data: skin rabbit, open Draize, 10 mg/24H mild; eye rabbit, standard Draize, 2 mg severe. Investigated as a tumorigen and mutagen.
--------\Cancer Lists\------------------------------------------------------
---NTP Carcinogen---
Ingredient Known Anticipated IARC Category
------------------------------------ ----- ----------- -------------
Pyridine (110-86-1) No No 3
Environmental Fate:
When released into the soil, this material is expected to readily biodegrade. When released into the soil, this material is expected to leach into groundwater. When released into the soil, this material is expected to have a half-life between 1 and 10 days. When released into water, this material may biodegrade to a moderate extent. When released into water, this material may evaporate to a moderate extent. This material is not expected to significantly bioaccumulate. When released into the air, this material may be moderately degraded by reaction with photochemically produced hydroxyl radicals. When released into the air, this material may be removed from the atmosphere to a moderate extent by wet deposition.
Environmental Toxicity:
This material may be toxic to aquatic life.
Whatever cannot be saved for recovery or recycling should be handled as hazardous waste and sent to a RCRA approved incinerator or disposed in a RCRA approved waste facility. Processing, use or contamination of this product may change the waste management options. State and local disposal regulations may differ from federal disposal regulations. Dispose of container and unused contents in accordance with federal, state and local requirements.
Domestic (Land, D.O.T.)
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Proper Shipping Name: PYRIDINE
Hazard Class: 3
UN/NA: UN1282
Packing Group: II
Information reported for product/size: 441LB
International (Water, I.M.O.)
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Proper Shipping Name: PYRIDINE
Hazard Class: 3
UN/NA: UN1282
Packing Group: II
Information reported for product/size: 441LB
--------\Chemical Inventory Status - Part 1\---------------------------------
Ingredient TSCA EC Japan Australia
----------------------------------------------- ---- --- ----- ---------
Pyridine (110-86-1) Yes Yes Yes Yes
--------\Chemical Inventory Status - Part 2\---------------------------------
--Canada--
Ingredient Korea DSL NDSL Phil.
----------------------------------------------- ----- --- ---- -----
Pyridine (110-86-1) Yes Yes No Yes
--------\Federal, State & International Regulations - Part 1\----------------
-SARA 302- ------SARA 313------
Ingredient RQ TPQ List Chemical Catg.
----------------------------------------- --- ----- ---- --------------
Pyridine (110-86-1) No No Yes No
--------\Federal, State & International Regulations - Part 2\----------------
-RCRA- -TSCA-
Ingredient CERCLA 261.33 8(d)
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Pyridine (110-86-1) 1000 U196 No
Chemical Weapons Convention: No TSCA 12(b): No CDTA: No
SARA 311/312: Acute: Yes Chronic: Yes Fire: Yes Pressure: No
Reactivity: No (Pure / Liquid)
WARNING:
THIS PRODUCT CONTAINS A CHEMICAL(S) KNOWN TO THE STATE OF CALIFORNIA TO CAUSE CANCER.
Australian Hazchem Code: 2WE
Poison Schedule: None allocated.
WHMIS:
This MSDS has been prepared according to the hazard criteria of the Controlled Products Regulations (CPR) and the MSDS contains all of the information required by the CPR.
NFPA Ratings: Health: 3 Flammability: 3 Reactivity: 0
Label Hazard Warning:
WARNING! FLAMMABLE LIQUID AND VAPOR. HARMFUL IF SWALLOWED, INHALED OR ABSORBED THROUGH SKIN. AFFECTS CENTRAL NERVOUS SYSTEM, LIVER AND KIDNEYS. CAUSES SEVERE IRRITATION TO EYES, SKIN AND RESPIRATORY TRACT.
Label Precautions:
Keep away from heat, sparks and flame.
Keep container closed.
Use only with adequate ventilation.
Avoid breathing vapor.
Avoid contact with eyes, skin and clothing.
Wash thoroughly after handling.
Label First Aid:
If swallowed, give large amounts of water to drink. Never give anything by mouth to an unconscious person. If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. In case of contact, immediately flush eyes or skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. In all cases get medical attention immediately.
Product Use:
Laboratory Reagent.
Revision Information:
No Changes.
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Prepared by: Environmental Health & Safety
Phone Number: (314) 654-1600 (U.S.A.)