MSDS Number: P0825 * * * * * Effective Date: 08/17/06 * * * * * Supercedes: 11/12/03 2,4-PENTANEDIONE


2,4-PENTANEDIONE


1. Product Identification

Synonyms: Acetoacetone; acetylacetone; diacetylmethane; pentanedione
CAS No.: 123-54-6
Molecular Weight: 100.11
Chemical Formula: CH3COCH2COCH3
Product Codes: S926, S985

2. Composition/Information on Ingredients


  Ingredient                                CAS No         Percent        Hazardous                                  
  ---------------------------------------   ------------   ------------   ---------   
 
  2,4-Pentanedione                          123-54-6         90 - 100%       Yes                                                                    
 

3. Hazards Identification

Emergency Overview
--------------------------
WARNING! FLAMMABLE LIQUID AND VAPOR. HARMFUL IF SWALLOWED, INHALED OR ABSORBED THROUGH SKIN. CAUSES IRRITATION TO SKIN, EYES AND RESPIRATORY TRACT. AFFECTS CENTRAL NERVOUS SYSTEM.

SAF-T-DATA(tm) Ratings (Provided here for your convenience)
-----------------------------------------------------------------------------------------------------------
Health Rating: 2 - Moderate (Poison)
Flammability Rating: 2 - Moderate
Reactivity Rating: 1 - Slight
Contact Rating: 3 - Severe
Lab Protective Equip: GOGGLES & SHIELD; LAB COAT & APRON; VENT HOOD; PROPER GLOVES; CLASS B EXTINGUISHER
Storage Color Code: Red (Flammable)
-----------------------------------------------------------------------------------------------------------

Potential Health Effects
----------------------------------

2,4-Pentanedione produces a clinically, anatomically, and morphologically distinct neurotoxic response which differs from that produced by the other ketones. (Patty, et al)

Inhalation:
Inhalation of vapors produces a narcotic effect. Symptoms of exposure may include drowsiness and irritation of the respiratory passages. Greater exposure may cause headache, dizziness, nausea, vomiting, and loss of consciousness.
Ingestion:
Symptoms may include irritation to the gastrointestinal tract and other symptoms paralleling inhalation exposure. May produce irreversible neurological impairment and possibly death.
Skin Contact:
Causes irritation. May be absorbed through the intact skin in harmful amounts.
Eye Contact:
Vapors are irritating to the eyes. Splashes are severely irritating with pain, redness.
Chronic Exposure:
Repeated exposure to low concentrations may be cumulative.
Aggravation of Pre-existing Conditions:
Persons with pre-existing neurological disorders may be more susceptible to the effects of the substance.

4. First Aid Measures

Inhalation:
Remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Call a physician.
Ingestion:
Give large amounts of water to drink. Never give anything by mouth to an unconscious person. Get medical attention.
Skin Contact:
Remove any contaminated clothing. Wash skin with soap or mild detergent and water for at least 15 minutes. Wash clothes before reuse. Get medical attention if irritation develops or persists.
Eye Contact:
Immediately flush eyes with plenty of water for at least 15 minutes, lifting lower and upper eyelids occasionally. Get medical attention immediately.

5. Fire Fighting Measures

Fire:
Flash point: 34C (93F) CC
Autoignition temperature: 335C (635F)
Flammable limits in air % by volume:
lel: 2.4; uel: 11.6
Flammable Liquid and Vapor!
Explosion:
Above flash point, vapor-air mixtures are explosive within flammable limits noted above. Vapors can flow along surfaces to distant ignition source and flash back. Sensitive to static discharge.
Fire Extinguishing Media:
Dry chemical, alcohol foam or carbon dioxide. Water spray may be used to keep fire exposed containers cool.
Special Information:
In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full facepiece operated in the pressure demand or other positive pressure mode. This highly flammable liquid must be kept from sparks, open flame, hot surfaces, and all sources of heat and ignition.

6. Accidental Release Measures

Ventilate area of leak or spill. Remove all sources of ignition. Wear appropriate personal protective equipment as specified in Section 8. Isolate hazard area. Keep unnecessary and unprotected personnel from entering. Contain and recover liquid when possible. Use non-sparking tools and equipment. Collect liquid in an appropriate container or absorb with an inert material (e. g., vermiculite, dry sand, earth), and place in a chemical waste container. Do not use combustible materials, such as saw dust. Do not flush to sewer! If a leak or spill has not ignited, use water spray to disperse the vapors, to protect personnel attempting to stop leak, and to flush spills away from exposures.


J. T. Baker SOLUSORB® solvent adsorbent is recommended for spills of this product.

7. Handling and Storage

Protect against physical damage. Store in a cool, dry well-ventilated location, away from any area where the fire hazard may be acute. Outside or detached storage is preferred. Separate from incompatibles. Containers should be bonded and grounded for transfers to avoid static sparks. Storage and use areas should be No Smoking areas. Use non-sparking type tools and equipment, including explosion proof ventilation. Containers of this material may be hazardous when empty since they retain product residues (vapors, liquid); observe all warnings and precautions listed for the product.

8. Exposure Controls/Personal Protection

Airborne Exposure Limits:
None established.
Ventilation System:
A system of local and/or general exhaust is recommended to keep employee exposures as low as possible. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area. Please refer to the ACGIH document, Industrial Ventilation, A Manual of Recommended Practices, most recent edition, for details.
Personal Respirators (NIOSH Approved):
For conditions of use where exposure to the substance is apparent, consult an industrial hygienist. For emergencies, or instances where the exposure levels are not known, use a full-facepiece positive-pressure, air-supplied respirator. WARNING: Air purifying respirators do not protect workers in oxygen-deficient atmospheres.
Skin Protection:
Rubber or neoprene gloves and additional protection including impervious boots, apron, or coveralls, as needed in areas of unusual exposure.
Eye Protection:
Use chemical safety goggles and/or a full face shield where splashing is possible. Maintain eye wash fountain and quick-drench facilities in work area.

9. Physical and Chemical Properties

Appearance:
Colorless to yellowish liquid.
Odor:
Pleasant odor.
Solubility:
Soluble in water, 12% w/w
Density:
0.975 @20/20C (68F)
pH:
No information found.
% Volatiles by volume @ 21C (70F):
100
Boiling Point:
140C (284F)
Melting Point:
-23C (-9F)
Vapor Density (Air=1):
3.5
Vapor Pressure (mm Hg):
7.0 @ 20C (68F)
Evaporation Rate (BuAc=1):
No information found.

10. Stability and Reactivity

Stability:
Stable under ordinary conditions of use and storage.
Hazardous Decomposition Products:
Carbon dioxide and carbon monoxide may form when heated to decomposition.
Hazardous Polymerization:
Will not occur.
Incompatibilities:
Oxidizing agents, zinc, copper, nickel and related alloys.
Conditions to Avoid:
Heat, flame, ignition sources, air, light and incompatibles.

11. Toxicological Information


Oral rat LD50: 55 mg/kg; skin rabbit LD50: 810 mg/kg; Irritation skin rabbit 488 mg open: mildly irritating; irritation eye rabbit 20 mg: severely irritating; inhalation rat LCLo: 1000 ppm/4H; investigated as a mutagen, reproductive effector.
  --------\Cancer Lists\------------------------------------------------------
                                         ---NTP Carcinogen---
  Ingredient                             Known    Anticipated    IARC Category
  ------------------------------------   -----    -----------    -------------
  2,4-Pentanedione (123-54-6)             No          No            None

12. Ecological Information

Environmental Fate:
When released into the soil, this material may biodegrade to a moderate extent. When released into the soil, this material is expected to leach into groundwater. When released into the soil, this material is expected to quickly evaporate. When released into water, this material may biodegrade to a moderate extent. This material has a log octanol-water partition coefficient of less than 3.0. This material is not expected to significantly bioaccumulate. When released into the air, this material may be moderately degraded by reaction with photochemically produced hydroxyl radicals. When released into the air, this material is expected to be readily removed from the atmosphere by wet deposition. When released into air, this material is expected to have a half-life between 10 and 30 days.
Environmental Toxicity:
96 Hr LC50 Pimephales promelas: 104 mg/L [flow-through];
96 Hr LC50 Lepomis macrochirus: 29 mg/L;
48 Hr EC50 Daphnia magna: 34.4 mg/L.

13. Disposal Considerations

Whatever cannot be saved for recovery or recycling should be handled as hazardous waste and sent to a RCRA approved incinerator or disposed in a RCRA approved waste facility. Processing, use or contamination of this product may change the waste management options. State and local disposal regulations may differ from federal disposal regulations. Dispose of container and unused contents in accordance with federal, state and local requirements.

14. Transport Information

Domestic (Land, D.O.T.)
-----------------------
Proper Shipping Name: PENTANE-2,4-DIONE
Hazard Class: 3, 6.1
UN/NA: UN2310
Packing Group: III
Information reported for product/size: 500ML

International (Water, I.M.O.)
-----------------------------
Proper Shipping Name: PENTANE-2,4-DIONE
Hazard Class: 3, 6.1
UN/NA: UN2310
Packing Group: III
Information reported for product/size: 500ML

International (Air, I.C.A.O.)
-----------------------------
Proper Shipping Name: PENTAN-2,4-DIONE
Hazard Class: 3
UN/NA: UN2310
Packing Group: III
Information reported for product/size: 500ML

15. Regulatory Information

  --------\Chemical Inventory Status - Part 1\---------------------------------
  Ingredient                                       TSCA  EC   Japan  Australia
  -----------------------------------------------  ----  ---  -----  ---------
  2,4-Pentanedione (123-54-6)                       Yes  Yes   Yes      Yes                                      
 
  --------\Chemical Inventory Status - Part 2\---------------------------------
                                                          --Canada--
  Ingredient                                       Korea  DSL   NDSL  Phil.
  -----------------------------------------------  -----  ---   ----  -----
  2,4-Pentanedione (123-54-6)                       Yes   Yes   No     Yes        
 
  --------\Federal, State & International Regulations - Part 1\----------------
                                             -SARA 302-    ------SARA 313------
  Ingredient                                 RQ    TPQ     List  Chemical Catg.
  -----------------------------------------  ---   -----   ----  --------------
  2,4-Pentanedione (123-54-6)                No    No      No         No
 
  --------\Federal, State & International Regulations - Part 2\----------------
                                                        -RCRA-    -TSCA-
  Ingredient                                 CERCLA     261.33     8(d) 
  -----------------------------------------  ------     ------    ------
  2,4-Pentanedione (123-54-6)                No         No         No      
 
 
Chemical Weapons Convention:  No     TSCA 12(b):  Yes    CDTA:  Yes
SARA 311/312:  Acute: Yes      Chronic: Yes  Fire: Yes Pressure: No
Reactivity: No          (Pure / Liquid)


Australian Hazchem Code: 2[S]
Poison Schedule: None allocated.
WHMIS:
This MSDS has been prepared according to the hazard criteria of the Controlled Products Regulations (CPR) and the MSDS contains all of the information required by the CPR.

16. Other Information

NFPA Ratings: Health: 2 Flammability: 2 Reactivity: 0
Label Hazard Warning:
WARNING! FLAMMABLE LIQUID AND VAPOR. HARMFUL IF SWALLOWED, INHALED OR ABSORBED THROUGH SKIN. CAUSES IRRITATION TO SKIN, EYES AND RESPIRATORY TRACT. AFFECTS CENTRAL NERVOUS SYSTEM.
Label Precautions:
Keep away from heat, sparks and flame.
Keep container closed.
Use with adequate ventilation.
Avoid breathing vapor.
Wash thoroughly after handling.
Avoid contact with eyes, skin and clothing.
Label First Aid:
In case of contact, immediately flush eyes or skin with plenty of water for at least 15 minutes. Remove contaminated clothing and shoes. Wash clothing before reuse. If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. If swallowed, give large amounts of water to drink. Never give anything by mouth to an unconscious person. In all cases, get medical attention.
Product Use:
For Laboratory, Research or Manufacturing Use.
Revision Information:
MSDS Section(s) changed since last revision of document include: 3, 12.
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Prepared by: Environmental Health & Safety
Phone Number: (314) 654-1600 (U.S.A.)