4-Methyl Pyridine (Picoline) MSDS
Section 1: Chemical Product and Company Identification
Product Name: 4-Methyl Pyridine (Picoline)
Catalog Codes: SLP1972
CAS#: 108-89-4
RTECS: UT5425000
TSCA: TSCA 8(b) inventory: 4-Methyl Pyridine (Picoline)
CI#: Not available.
Synonym: 4-Methylpryridine; p-Picoline; p-Methylpyridine
Chemical Name: 4-Picoline
Chemical Formula: C6-H7-N
Section 2: Composition and Information on Ingredients
Composition:
Name CAS # % by Weight
{4-} Methyl Pyridine (Picoline) 108-89-4 100
Toxicological Data on Ingredients: 4- Methyl Pyridine (Picoline): ORAL (LD50): Acute: 440 mg/kg [Rat]. 350 mg/kg [Mouse].
Section 3: Hazards Identification
Potential Acute Health Effects:
Hazardous in case of skin contact (irritant, permeator), of eye contact (irritant), of ingestion, of inhalation (lung
irritant). Severe over-exposure can result in death.
Potential Chronic Health Effects:
CARCINOGENIC EFFECTS: Not available.
MUTAGENIC EFFECTS: Not available.
TERATOGENIC EFFECTS: Not available.
DEVELOPMENTAL TOXICITY: Not available.
The substance may be toxic to kidneys, liver, central nervous system (CNS).
Repeated or prolonged exposure to the substance can produce target organs damage. Repeated exposure to a
highly toxic material may produce general deterioration of health by an accumulation in one or many human
organs.
Section 4: First Aid Measures
Eye Contact:
Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at
least 15 minutes. Cold water may be used. Get medical attention.
Skin Contact:
In case of contact, immediately flush skin with plenty of water for at least 15 minutes while removing contaminated
clothing and shoes. Cover the irritated skin with an emollient. Cold water may be used.Wash clothing before
reuse. Thoroughly clean shoes before reuse. Get medical attention immediately.
Serious Skin Contact:
Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek immediate
medical attention.
Inhalation:
If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get
medical attention.
Serious Inhalation:
Evacuate the victim to a safe area as soon as possible. Loosen tight clothing such as a collar, tie, belt or
waistband. If breathing is difficult, administer oxygen. If the victim is not breathing, perform mouth-to-mouth
resuscitation. WARNING: It may be hazardous to the person providing aid to give mouth-to-mouth resuscitation
when the inhaled material is toxic, infectious or corrosive. Seek medical attention.
Ingestion:
Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an
unconscious person. If large quantities of this material are swallowed, call a physician immediately. Loosen tight
clothing such as a collar, tie, belt or waistband.
Serious Ingestion: Not available.
Section 5: Fire and Explosion Data
Flammability of the Product: Flammable.
Auto-Ignition Temperature: Not available.
Flash Points: CLOSED CUP: 40°C (104°F). OPEN CUP: 57°C (134.6°F).
Flammable Limits: LOWER: 1.3% UPPER: 8.7%
Products of Combustion: These products are carbon oxides (CO, CO2).
Fire Hazards in Presence of Various Substances: Flammable in presence of open flames and sparks, of heat.
Explosion Hazards in Presence of Various Substances:
Risks of explosion of the product in presence of mechanical impact: Not available.
Risks of explosion of the product in presence of static discharge: Not available.
Fire Fighting Media and Instructions:
Flammable liquid, soluble or dispersed in water.
SMALL FIRE: Use DRY chemical powder.
LARGE FIRE: Use alcohol foam, water spray or fog. Cool containing vessels with water jet in order to prevent
pressure build-up, autoignition or explosion.
Special Remarks on Fire Hazards: Not available.
Special Remarks on Explosion Hazards: Forms explosive mixture with air above 134 F.
Section 6: Accidental Release Measures
Small Spill:
Dilute with water and mop up, or absorb with an inert dry material and place in an appropriate waste disposal
container.
Large Spill:
Flammable liquid. Poisonous liquid.
Keep away from heat. Keep away from sources of ignition. Stop leak if without risk. Absorb with DRY earth,
sand or other non-combustible material. Do not get water inside container. Do not touch spilled material. Use
water spray to reduce vapors. Prevent entry into sewers, basements or confined areas; dike if needed. Call for
assistance on disposal. Be careful that the product is not present at a concentration level above TLV. Check TLV
on the MSDS and with local authorities.
Section 7: Handling and Storage
Precautions:
Keep locked up.. Keep away from heat. Keep away from sources of ignition. Ground all equipment containing
material. Do not ingest. Do not breathe gas/fumes/ vapor/spray. Wear suitable protective clothing. In case of
insufficient ventilation, wear suitable respiratory equipment. If ingested, seek medical advice immediately and
show the container or the label. Avoid contact with skin and eyes. Keep away from incompatibles such as
oxidizing agents, acids, moisture.
Storage:
HYGROCOPIC. Store in a segregated and approved area. Keep container in a cool, well-ventilated area. Keep
container tightly closed and sealed until ready for use. Avoid all possible sources of ignition (spark or flame). Do
not store above 23°C (73.4°F).
Section 8: Exposure Controls/Personal Protection
Engineering Controls:
Provide exhaust ventilation or other engineering controls to keep the airborne concentrations of vapors below their
respective threshold limit value. Ensure that eyewash stations and safety showers are proximal to the
work-station location.
Personal Protection:
Splash goggles. Lab coat. Vapor respirator. Be sure to use an approved/certified respirator or equivalent.
Gloves.
Personal Protection in Case of a Large Spill:
Splash goggles. Full suit. Vapor respirator. Boots. Gloves. A self contained breathing apparatus should be
used to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist
BEFORE handling this product.
Exposure Limits:
STEL: 5 from AIHA
STEL: 19 (mg/m3) from AIHA
Consult local authorities for acceptable exposure limits.
Section 9: Physical and Chemical Properties
Physical state and appearance: Liquid.
Odor: Obnoxious. Sweetish.
Taste: Not available.
Molecular Weight: 93.13 g/mole
Color: Clear Colorless to light yellow.
pH (1% soln/water): Not available.
Boiling Point: 144.5°C (292.1°F)
Melting Point: 3.6°C (38.5°F)
Critical Temperature: Not available.
Specific Gravity: 0.957 (Water = 1)
Vapor Pressure: Not available.
Vapor Density: Not available.
Volatility: Not available.
Odor Threshold: Not available.
Water/Oil Dist. Coeff.: The product is more soluble in oil; log(oil/water) = 1.2
Ionicity (in Water): Not available.
Dispersion Properties: See solubility in water, diethyl ether, acetone.
Solubility: Soluble in cold water, diethyl ether, acetone.
Section 10: Stability and Reactivity Data
Stability: The product is stable.
Instability Temperature: Not available.
Conditions of Instability: Excess heat, ignition sources, incompatible materials
Incompatibility with various substances: Reactive with oxidizing agents, acids, moisture.
Corrosivity: Not available.
Special Remarks on Reactivity: HYGROSCOPIC. Incompatible with oxidizing agents, isocyanates, organic anydrides,
moisture, and water.
Special Remarks on Corrosivity: Not available.
Polymerization: Will not occur.
Section 11: Toxicological Information
Routes of Entry: Absorbed through skin. Dermal contact. Eye contact.
Toxicity to Animals: Acute oral toxicity (LD50): 350 mg/kg [Mouse].
Chronic Effects on Humans: May cause damage to the following organs: kidneys, liver, central nervous system (CNS).
Other Toxic Effects on Humans: Hazardous in case of skin contact (irritant, permeator), of ingestion, of inhalation (lung
irritant).
Special Remarks on Toxicity to Animals: Not available.
Special Remarks on Chronic Effects on Humans: Not available.
Special Remarks on other Toxic Effects on Humans:
Acute Potential Health Effects:
Skin: Causes skin irritation (redness, rash, erruptions). It readily absorbed through the skin and may be harmful
if absorbed through the skin. May cause cyanosis of athe extremeties.
Eyes: Causes eye irritation. May cause chemical conjunctivits and corneal damage.
Inhalation: Causes irritation of the respiratory tract and mucous membranes. Aspiration may lead to pulmonary
edema. Vapors may affect behavior and the central nervous system (dizziness, headaches, giddiness).
Exposure by inhalation may also give rise to flushing of the face, skin rash, nausea, vomiting, and a burning
sensation in the chest, and an increase in heart and respiration rates.
Ingestion: May cause irritation of the digestive tract (diarrhea, vomiting, weight loss). Ingestion of large amounts
may affect behavior and central nervous system (depression, ataxia, weakness, unconciouness),
Section 12: Ecological Information
Ecotoxicity:
Ecotoxicity in water (LC50): 400 mg/l 96 hours [Fathead Minnow]. 22.9 ppm 96 hours [Rainbow Trout]. 22.1
ppm 96 hours [Water Flea].
BOD5 and COD: Not available.
Products of Biodegradation:
Possibly hazardous short term degradation products are not likely. However, long term degradation products may
arise.
Toxicity of the Products of Biodegradation: The products of degradation are less toxic than the product itself.
Special Remarks on the Products of Biodegradation: Not available.
Section 13: Disposal Considerations
Waste Disposal:
Waste must be disposed of in accordance with federal, state and local environmental
control regulations.
Section 14: Transport Information
DOT Classification: CLASS 3: Flammable liquid.
Identification: : Picolines UNNA: 2313 PG: III
Special Provisions for Transport: Not available.
Section 15: Other Regulatory Information
Federal and State Regulations:
Pennsylvania RTK: 4-Picoline
Florida: 4-Picoline
Massachusetts RTK: 4-Picoline
TSCA 8(b) inventory: 4-Picoline
TSCA 8(d) H and S data reporting: 4-Picoline: Effective: 9/10/84; Sunset: 9/10/94
Other Regulations:
OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200).
EINECS: This product is on the European Inventory of Existing Commercial Chemical Substances.
Other Classifications:
WHMIS (Canada):
CLASS B-2: Flammable liquid with a flash point lower than 37.8°C (100°F).
CLASS D-1B: Material causing immediate and serious toxic effects (TOXIC).
DSCL (EEC):
R10- Flammable.
R20/22- Harmful by inhalation and if
swallowed.
R24- Toxic in contact with skin.
R36/37/38- Irritating to eyes,
respiratory system and skin.
S9- Keep container in a well-ventilated place.
S16- Keep away from sources of ignition - No
smoking.
S26- In case of contact with eyes, rinse
immediately with plenty of water and seek
medical advice.
S33- Take precautionary measures against
static discharges.
S36- Wear suitable protective clothing.
S45- In case of accident or if you feel unwell,
seek medical advice immediately (show the
label where possible).
HMIS (U.S.A.):
Health Hazard: 2
Fire Hazard: 2
Reactivity: 0
Personal Protection: h
National Fire Protection Association (U.S.A.):
Health: 2
Flammability: 2
Reactivity: 0
Specific hazard:
Protective Equipment:
Gloves.
Lab coat.
Vapor respirator. Be sure to use an
approved/certified respirator or
equivalent. Wear appropriate respirator
when ventilation is inadequate.
Splash goggles.
Section 16: Other Information
References: Not available.
Other Special Considerations: Not available.
Created: 10/10/2005 11:27 AM
Last Updated: 11/06/2008 12:00 PM