5-Fluorouracil Extra Pure MSDS

5-Fluorouracil Extra Pure MSDS

 

Section 1: Chemical Product and Company Identification

Product Name: 5-Fluorouracil Extra Pure

Catalog Codes: SLF2023

CAS#: 51-21-8

RTECS: YR0350000

TSCA: TSCA 8(b) inventory: 5-Fluorouracil Extra Pure

CI#: Not available.

Synonym: 5-Fluoro-2,4(1H,3H)-pyrimidinedione

Chemical Formula: C4H3FN2O2

 

Section 2: Composition and Information on Ingredients

Composition:

Name CAS # % by Weight

{5-}Fluorouracil 51-21-8 100

Toxicological Data on Ingredients: 5-Fluorouracil: ORAL (LD50): Acute: 230 mg/kg [Rat]. 115 mg/kg [Mouse].

 

Section 3: Hazards Identification

Potential Acute Health Effects:

Very hazardous in case of skin contact (irritant), of ingestion. Hazardous in case of inhalation. Slightly hazardous

in case of skin contact (permeator), of eye contact (irritant). Severe over-exposure can result in death.

Potential Chronic Health Effects:

CARCINOGENIC EFFECTS: Not available.

MUTAGENIC EFFECTS: Not available.

TERATOGENIC EFFECTS: Not available.

DEVELOPMENTAL TOXICITY: Not available.

The substance is toxic to blood.

Repeated or prolonged exposure to the substance can produce target organs damage. Repeated exposure to an

highly toxic material may produce general deterioration of health by an accumulation in one or many human

organs.

 

Section 4: First Aid Measures

Eye Contact: Immediately flush eyes with running water for at least 15 minutes, keeping eyelids open. Cold water may be

used.

Skin Contact:

After contact with skin, wash immediately with plenty of water. Gently and thoroughly wash the contaminated skin

with running water and non-abrasive soap. Be particularly careful to clean folds, crevices, creases and groin.

Cold water may be used. Cover the irritated skin with an emollient. If irritation persists, seek medical attention.

Wash contaminated clothing before reusing.

Serious Skin Contact:

Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek immediate

medical attention.

Inhalation: Allow the victim to rest in a well ventilated area. Seek immediate medical attention.

Serious Inhalation:

Evacuate the victim to a safe area as soon as possible. Loosen tight clothing such as a collar, tie, belt or

waistband. If breathing is difficult, administer oxygen. If the victim is not breathing, perform mouth-to-mouth

resuscitation. Seek medical attention.

Ingestion:

Do not induce vomiting. Examine the lips and mouth to ascertain whether the tissues are damaged, a possible

indication that the toxic material was ingested; the absence of such signs, however, is not conclusive. Loosen

tight clothing such as a collar, tie, belt or waistband. If the victim is not breathing, perform mouth-to-mouth

resuscitation. Seek immediate medical attention.

Serious Ingestion: Not available.

 

Section 5: Fire and Explosion Data

Flammability of the Product: May be combustible at high temperature.

Auto-Ignition Temperature: Not available.

Flash Points: Not available.

Flammable Limits: Not available.

Products of Combustion: These products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...), halogenated

compounds.

Fire Hazards in Presence of Various Substances: Not available.

Explosion Hazards in Presence of Various Substances:

Risks of explosion of the product in presence of mechanical impact: Not available.

Risks of explosion of the product in presence of static discharge: Not available.

Fire Fighting Media and Instructions:

SMALL FIRE: Use DRY chemical powder.

LARGE FIRE: Use water spray, fog or foam. Do not use water jet.

Special Remarks on Fire Hazards: Not available.

Special Remarks on Explosion Hazards: Not available.

 

Section 6: Accidental Release Measures

Small Spill: Use appropriate tools to put the spilled solid in a convenient waste disposal container.

Large Spill: Use a shovel to put the material into a convenient waste disposal container.

 

Section 7: Handling and Storage

Precautions:

Keep locked up Keep away from heat. Keep away from sources of ignition. Empty containers pose a fire risk,

evaporate the residue under a fume hood. Ground all equipment containing material. Do not ingest. Do not

breathe dust. Avoid contact with skin Wear suitable protective clothing In case of insufficient ventilation, wear

suitable respiratory equipment If ingested, seek medical advice immediately and show the container or the label.

Storage:

Keep container dry. Keep in a cool place. Ground all equipment containing material. Keep container tightly

closed. Keep in a cool, well-ventilated place. Highly toxic or infectious materials should be stored in a separate

locked safety storage cabinet or room.

 

Section 8: Exposure Controls/Personal Protection

Engineering Controls:

Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below

recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to

airborne contaminants below the exposure limit.

Personal Protection: Safety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent.

Gloves.

Personal Protection in Case of a Large Spill:

Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used

to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist

BEFORE handling this product.

Exposure Limits: Not available.

 

Section 9: Physical and Chemical Properties

Physical state and appearance: Solid. (Solid crystalline powder.)

Odor: Odorless.

Taste: Not available.

Molecular Weight: 130.08 g/mole

Color: White.

pH (1% soln/water): Not available.

Boiling Point: Not available.

Melting Point: Decomposes. (282°C or 539.6°F)

Critical Temperature: Not available.

Specific Gravity: Not available.

Vapor Pressure: Not applicable.

Vapor Density: Not available.

Volatility: Not available.

Odor Threshold: Not available.

Water/Oil Dist. Coeff.: Not available.

Ionicity (in Water): Not available.

Dispersion Properties: See solubility in water, methanol.

Solubility:

Partially soluble in cold water, methanol.

Insoluble in diethyl ether.

 

Section 10: Stability and Reactivity Data

Stability: The product is stable.

Instability Temperature: Not available.

Conditions of Instability: Not available.

Incompatibility with various substances: Not available.

Corrosivity: Not available.

Special Remarks on Reactivity: Not available.

Special Remarks on Corrosivity: Not available.

Polymerization: No.

 

Section 11: Toxicological Information

Routes of Entry: Absorbed through skin. Inhalation. Ingestion.

Toxicity to Animals: Acute oral toxicity (LD50): 115 mg/kg [Mouse].

Chronic Effects on Humans: The substance is toxic to blood.

Other Toxic Effects on Humans:

Very hazardous in case of skin contact (irritant), of ingestion.

Hazardous in case of inhalation.

Slightly hazardous in case of skin contact (permeator).

Special Remarks on Toxicity to Animals: Not available.

Special Remarks on Chronic Effects on Humans: Not available.

Special Remarks on other Toxic Effects on Humans: Not available.

 

Section 12: Ecological Information

Ecotoxicity: Not available.

BOD5 and COD: Not available.

Products of Biodegradation:

Possibly hazardous short term degradation products are not likely. However, long term degradation products may

arise.

Toxicity of the Products of Biodegradation: The products of degradation are as toxic as the original product.

Special Remarks on the Products of Biodegradation: Not available.

 

Section 13: Disposal Considerations

Waste Disposal:

 

Section 14: Transport Information

DOT Classification:

Identification:

Special Provisions for Transport: Not available.

 

Section 15: Other Regulatory Information

Federal and State Regulations:

California prop. 65: This product contains the following ingredients for which the State of California has found to

cause cancer, birth defects or other reproductive harm, which would require a warning under the statute:

5-Fluorouracil

California prop. 65: This product contains the following ingredients for which the State of California has found to

cause birth defects which would require a warning under the statute: 5-Fluorouracil

Pennsylvania RTK: 5-Fluorouracil

Massachusetts RTK: 5-Fluorouracil

TSCA 8(b) inventory: 5-Fluorouracil

SARA 302/304/311/312 extremely hazardous substances: 5-Fluorouracil

SARA 313 toxic chemical notification and release reporting: 5-Fluorouracil

CERCLA: Hazardous substances.: 5-Fluorouracil

Other Regulations: OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200).

Other Classifications:

WHMIS (Canada):

CLASS D-1B: Material causing immediate and serious toxic effects (TOXIC).

CLASS D-2B: Material causing other toxic effects (TOXIC).

DSCL (EEC):

R38- Irritating to skin.

R48/22- Harmful: danger of serious

damage to health by prolonged

exposure if swallowed.

HMIS (U.S.A.):

Health Hazard: 2

Fire Hazard: 1

Reactivity: 0

Personal Protection: E

National Fire Protection Association (U.S.A.):

Health: 2

Flammability: 1

Reactivity: 0

Specific hazard:

Protective Equipment:

Gloves.

Lab coat.

Dust respirator. Be sure to use an

approved/certified respirator or

equivalent. Wear appropriate respirator

when ventilation is inadequate.

Safety glasses.

 

Section 16: Other Information

References: Not available.

Other Special Considerations: Not available.

Created: 10/09/2005 05:34 PM

Last Updated: 11/06/2008 12:00 PM