Colchicine MSDS

Section 1: Chemical Product and Company Identification

Product Name: Colchicine

Catalog Codes: SLC1345

CAS#: 64-86-8

RTECS: GH0700000

TSCA: TSCA 8(b) inventory: Colchicine

CI#: Not available.

Synonym:

N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[alpha]heptalen-7-yl)acetamide

Chemical Formula: C22H25NO6

Section 2: Composition and Information on Ingredients

Composition:

Name CAS # % by Weight

Colchicine 64-86-8 100

Toxicological Data on Ingredients: Colchicine: ORAL (LD50): Acute: 6 mg/kg [Mouse].

Section 3: Hazards Identification

Potential Acute Health Effects:

Extremely hazardous in case of skin contact (corrosive, irritant, sensitizer, permeator), of eye contact (irritant), of

ingestion, of inhalation. The amount of tissue damage depends on length of contact. Eye contact can result in

corneal damage or blindness. Skin contact can produce inflammation and blistering. Inhalation of dust will

produce irritation to gastro-intestinal or respiratory tract, characterized by burning, sneezing and coughing.

Severe over-exposure can produce lung damage, choking, unconsciousness or death. Inflammation of the eye is

characterized by redness, watering, and itching. Skin inflammation is characterized by itching, scaling, reddening,

or, occasionally, blistering.

Potential Chronic Health Effects:

Extremely hazardous in case of skin contact (corrosive, irritant, sensitizer, permeator), of eye contact (irritant), of

ingestion, of inhalation.

CARCINOGENIC EFFECTS: Not available.

MUTAGENIC EFFECTS: Not available.

TERATOGENIC EFFECTS: Not available.

DEVELOPMENTAL TOXICITY: PROVEN

The substance is toxic to blood, kidneys, lungs, the nervous system, the reproductive system, liver, mucous

membranes.

Repeated or prolonged exposure to the substance can produce target organs damage. Repeated exposure of the

eyes to a low level of dust can produce eye irritation. Repeated skin exposure can produce local skin destruction,

or dermatitis. Repeated inhalation of dust can produce varying degree of respiratory irritation or lung damage.

Repeated exposure to an highly toxic material may produce general deterioration of health by an accumulation in

one or many human organs. Repeated or prolonged inhalation of dust may lead to chronic respiratory irritation.

Section 4: First Aid Measures

Eye Contact:

Check for and remove any contact lenses. Immediately flush eyes with running water for at least 15 minutes,

keeping eyelids open. Cold water may be used. Do not use an eye ointment. Seek medical attention.

Skin Contact:

If the chemical got onto the clothed portion of the body, remove the contaminated clothes as quickly as possible,

protecting your own hands and body. Place the victim under a deluge shower. If the chemical got on the victim's

exposed skin, such as the hands : Gently and thoroughly wash the contaminated skin with running water and

non-abrasive soap. Be particularly careful to clean folds, crevices, creases and groin. Cold water may be used.

If irritation persists, seek medical attention. Wash contaminated clothing before reusing.

Serious Skin Contact:

Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek immediate

medical attention.

Inhalation: Allow the victim to rest in a well ventilated area. Seek immediate medical attention.

Serious Inhalation:

Evacuate the victim to a safe area as soon as possible. Loosen tight clothing such as a collar, tie, belt or

waistband. If breathing is difficult, administer oxygen. If the victim is not breathing, perform mouth-to-mouth

resuscitation. WARNING: It may be hazardous to the person providing aid to give mouth-to-mouth resuscitation

when the inhaled material is toxic, infectious or corrosive. Seek immediate medical attention.

Ingestion:

Do not induce vomiting. Examine the lips and mouth to ascertain whether the tissues are damaged, a possible

indication that the toxic material was ingested; the absence of such signs, however, is not conclusive. Loosen

tight clothing such as a collar, tie, belt or waistband. If the victim is not breathing, perform mouth-to-mouth

resuscitation. Seek immediate medical attention.

Serious Ingestion: Not available.

Section 5: Fire and Explosion Data

Flammability of the Product: May be combustible at high temperature.

Auto-Ignition Temperature: Not available.

Flash Points: Not available.

Flammable Limits: Not available.

Products of Combustion: These products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...).

Fire Hazards in Presence of Various Substances: Not available.

Explosion Hazards in Presence of Various Substances:

Risks of explosion of the product in presence of mechanical impact: Not available.

Risks of explosion of the product in presence of static discharge: Not available.

Fire Fighting Media and Instructions:

SMALL FIRE: Use DRY chemical powder.

LARGE FIRE: Use water spray, fog or foam. Do not use water jet.

Special Remarks on Fire Hazards: Not available.

Special Remarks on Explosion Hazards: Not available.

Section 6: Accidental Release Measures

Small Spill: Use appropriate tools to put the spilled solid in a convenient waste disposal container.

Large Spill:

Corrosive solid.

Stop leak if without risk. Do not get water inside container. Do not touch spilled material. Use water spray to

reduce vapors. Prevent entry into sewers, basements or confined areas; dike if needed. Eliminate all ignition

sources. Call for assistance on disposal.

Section 7: Handling and Storage

Precautions:

Keep locked up Keep container dry. Keep away from heat. Keep away from sources of ignition. Empty

containers pose a fire risk, evaporate the residue under a fume hood. Ground all equipment containing material.

Do not ingest. Do not breathe dust. Never add water to this product In case of insufficient ventilation, wear

suitable respiratory equipment If ingested, seek medical advice immediately and show the container or the label.

Avoid contact with skin and eyes

Storage:

Keep container dry. Keep in a cool place. Ground all equipment containing material. Corrosive materials should

be stored in a separate safety storage cabinet or room.

Section 8: Exposure Controls/Personal Protection

Engineering Controls:

Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below

recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to

airborne contaminants below the exposure limit.

Personal Protection:

Splash goggles. Synthetic apron. Vapor and dust respirator. Be sure to use an approved/certified respirator or

equivalent. Gloves.

Personal Protection in Case of a Large Spill:

Splash goggles. Full suit. Vapor and dust respirator. Boots. Gloves. A self contained breathing apparatus

should be used to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a

specialist BEFORE handling this product.

Exposure Limits: Not available.

Section 9: Physical and Chemical Properties

Physical state and appearance: Solid.

Odor: Not available.

Taste: Not available.

Molecular Weight: 399.45 g/mole

Color: Not available.

pH (1% soln/water): 6 [Acidic.]

Boiling Point: Decomposes.

Melting Point: 146°C (294.8°F)

Critical Temperature: Not available.

Specific Gravity: Not available.

Vapor Pressure: Not applicable.

Vapor Density: Not available.

Volatility: Not available.

Odor Threshold: Not available.

Water/Oil Dist. Coeff.: Not available.

Ionicity (in Water): Not available.

Dispersion Properties: See solubility in water.

Solubility: Partially soluble in cold water.

Section 10: Stability and Reactivity Data

Stability: The product is stable.

Instability Temperature: Not available.

Conditions of Instability: Not available.

Incompatibility with various substances: Not available.

Corrosivity: Non-corrosive in presence of glass.

Special Remarks on Reactivity: Not available.

Special Remarks on Corrosivity: Not available.

Polymerization: No.

Section 11: Toxicological Information

Routes of Entry: Dermal contact. Eye contact. Inhalation. Ingestion.

Toxicity to Animals: Acute oral toxicity (LD50): 6 mg/kg [Mouse].

Chronic Effects on Humans:

DEVELOPMENTAL TOXICITY: PROVEN

The substance is toxic to blood, kidneys, lungs, the nervous system, the reproductive system, liver, mucous

membranes.

Other Toxic Effects on Humans: Extremely hazardous in case of skin contact (corrosive, irritant, sensitizer, permeator), of

ingestion, of inhalation.

Special Remarks on Toxicity to Animals: Not available.

Special Remarks on Chronic Effects on Humans: Excreted in maternal milk in human.

Special Remarks on other Toxic Effects on Humans: Not available.

Section 12: Ecological Information

Ecotoxicity: Not available.

BOD5 and COD: Not available.

Products of Biodegradation:

Possibly hazardous short term degradation products are not likely. However, long term degradation products may

arise.

Toxicity of the Products of Biodegradation: The products of degradation are less toxic.

Special Remarks on the Products of Biodegradation: Not available.

Section 13: Disposal Considerations

Waste Disposal:

Section 14: Transport Information

DOT Classification: CLASS 6.1: Poisonous material.

Identification: : Alkaloid, solid, n.o.s. (Colchicine) : UN1544 PG: II

Special Provisions for Transport: Not available.

Section 15: Other Regulatory Information

Federal and State Regulations:

California prop. 65: This product contains the following ingredients for which the State of California has found to

cause cancer, birth defects or other reproductive harm, which would require a warning under the statute:

Colchicine

California prop. 65: This product contains the following ingredients for which the State of California has found to

cause birth defects which would require a warning under the statute: Colchicine

Pennsylvania RTK: Colchicine

Massachusetts RTK: Colchicine

TSCA 8(b) inventory: Colchicine

SARA 302/304/311/312 extremely hazardous substances: Colchicine

CERCLA: Hazardous substances.: Colchicine

Other Regulations: OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200).

Other Classifications:

WHMIS (Canada):

CLASS D-1A: Material causing immediate and serious toxic effects (VERY TOXIC).

CLASS D-2A: Material causing other toxic effects (VERY TOXIC).

DSCL (EEC):

R35- Causes severe burns.

R43- May cause sensitization by skin

contact.

HMIS (U.S.A.):

Health Hazard: 4

Fire Hazard: 1

Reactivity: 0

Personal Protection: j

National Fire Protection Association (U.S.A.):

Health: 4

Flammability: 1

Reactivity: 0

Specific hazard:

Protective Equipment:

Gloves.

Synthetic apron.

Vapor and dust respirator. Be sure to

use an approved/certified respirator or

equivalent. Wear appropriate respirator

when ventilation is inadequate.

Splash goggles.

Section 16: Other Information

References: Not available.

Other Special Considerations: Not available.

Created: 10/09/2005 04:58 PM

Last Updated: 11/06/2008 12:00 PM