Synonyms: Ammonium N-hydroxy-N-nitrosobenzenamine; ammonium salt of N-nitrosophenylhydroxylamine; Inhibitor NPH;Benzenamine,N-hydroxy-N- nitroso-,ammonium salt
CAS No.: 135-20-6
Molecular Weight: 155
Chemical Formula: C6H9N3O2
Product Codes: 1760
Ingredient CAS No Percent Hazardous --------------------------------------- ------------ ------------ --------- Cupferron 135-20-6 90 - 100% Yes
Emergency Overview
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WARNING! POSSIBLE CANCER HAZARD. MAY CAUSE CANCER BASED ON ANIMAL DATA. Risk of cancer depends on duration and level of exposure. CAUSES IRRITATION TO SKIN, EYES AND RESPIRATORY TRACT. HARMFUL IF SWALLOWED, INHALED OR ABSORBED THROUGH SKIN.
SAF-T-DATA(tm) Ratings (Provided here for your convenience)
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Health Rating: 3 - Severe (Cancer Causing)
Flammability Rating: 1 - Slight
Reactivity Rating: 1 - Slight
Contact Rating: 2 - Moderate (Life)
Lab Protective Equip: GOGGLES; LAB COAT; VENT HOOD; PROPER GLOVES
Storage Color Code: Blue (Health)
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Potential Health Effects
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The acute and chronic systemic toxicity in man from exposure to Cupferron-ammonium salt (NPH/NH4) has not been well documented; however, any exposure may constitute a route of absorption.
Inhalation:
May cause irritation to the respiratory tract. Symptoms may include coughing and shortness of breath.
Ingestion:
Toxic. May cause some gastrointestinal disturbances. Animal studies suggest that oral ingestion causes acute systemic effects.
Skin Contact:
Causes irritation to skin. Symptoms include redness, itching, and pain. May be absorbed through the skin with possible systemic effects.
Eye Contact:
Causes irritation, redness, and pain.
Chronic Exposure:
Chronic exposure may occur from inhalation, ingestion or skin absorption. A bioassay was conducted by the National Cancer Institute (NCI) by feeding diets ranging from 0.15 percent to 0.4 percent NPH/ammonium salt to rats and mice. Under conditions of the bioassay, NPH showed dose-related carcinogenic effects. In addition to causing hemangiosarcomas, the primary target organs were the forestomach, liver, auditory sebaceous glands, and the harderian glands.
Aggravation of Pre-existing Conditions:
Persons with pre-existing skin disorders or eye problems, or impaired liver or respiratory function may be more susceptible to the effects of the substance.
Inhalation:
Remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention.
Ingestion:
Induce vomiting immediately as directed by medical personnel. Never give anything by mouth to an unconscious person. Get medical attention.
Skin Contact:
Immediately flush skin with plenty of water for at least 15 minutes. Remove contaminated clothing and shoes. Get medical attention. Wash clothing before reuse. Thoroughly clean shoes before reuse. Contaminated work clothes should be laundered by individuals who have been informed of the hazards of exposure to this substance.
Eye Contact:
Immediately flush eyes with plenty of water for at least 15 minutes, lifting lower and upper eyelids occasionally. Get medical attention immediately.
Fire:
As with most organic solids, fire is possible at elevated temperatures or by contact with an ignition source. Poisonous gases are produced in fire, including ammonia and nitrogen oxides. Fine dust dispersed in air in sufficient concentrations, and in the presence of an ignition source is a potential dust explosion hazard.
Explosion:
Fine dust dispersed in air in sufficient concentrations, and in the presence of an ignition source is a potential dust explosion hazard.
Fire Extinguishing Media:
Water spray, dry chemical, alcohol foam, or carbon dioxide.
Special Information:
In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full facepiece operated in the pressure demand or other positive pressure mode.
Ventilate area of leak or spill. Wear appropriate personal protective equipment as specified in Section 8. Spills: Sweep up and containerize for reclamation or disposal. Vacuuming or wet sweeping may be used to avoid dust dispersal.
Keep in a tightly closed container, stored in a cool, dry, ventilated area. Protect against physical damage. A few percent of ammonium carbonate chips are added to the product as a stabilizer. Repeated opening of the container can deplete the ammonium carbonate and reduce the shelf life. Isolate from strong oxidizers and acids. Isolate from incompatible substances. Wear special protective equipment (Sec. 8) for maintenance break-in or where exposures may exceed established exposure levels. Wash hands, face, forearms and neck when exiting restricted areas. Shower, dispose of outer clothing, change to clean garments at the end of the day. Avoid cross-contamination of street clothes. Wash hands before eating and do not eat, drink, or smoke in workplace. Containers of this material may be hazardous when empty since they retain product residues (dust, solids); observe all warnings and precautions listed for the product.
Airborne Exposure Limits:
Mallinckrodt recommends exposure levels be kept below 0.1 mg/m3 (TWA) - Cupferron
Ammonia:
-OSHA Permissible Exposure Limit (PEL):50 ppm
-ACGIH Threshold Limit Value (TLV):25 ppm (TWA), 35 ppm(STEL)
Ventilation System:
A system of local and/or general exhaust is recommended to keep employee exposures below the Airborne Exposure Limits. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area. Please refer to the ACGIH document, Industrial Ventilation, A Manual of Recommended Practices, most recent edition, for details.
Personal Respirators (NIOSH Approved):
If the exposure limit is exceeded and engineering controls are not feasible, a half-face respirator with an ammonia/methylamine cartridge may be worn for up to ten times the exposure limit or the maximum use concentration specified by the appropriate regulatory agency or respirator supplier, whichever is lowest. A full-face piece respirator with an ammonia/methylamine cartridge may be worn up to 50 times the exposure limit, or the maximum use concentration specified by the appropriate regulatory agency, or respirator supplier, whichever is lowest. For emergencies or instances where the exposure levels are not known, use a full-facepiece positive-pressure, air-supplied respirator. WARNING: Air-purifying respirators do not protect workers in oxygen-deficient atmospheres.
Skin Protection:
Wear impervious protective clothing, including boots, gloves, lab coat, apron or coveralls, as appropriate, to prevent skin contact. Coveralls should be disposable or laundered freshly every day.
Eye Protection:
Maintain eye wash fountain and quick-drench facilities in work area. Use chemical safety goggles and/or full face shield where dusting or splashing of solutions is possible.
Appearance:
White to pale yellow crystals.
Odor:
Slight ammonia odor.
Solubility:
Soluble in water, 10gm/100ml.
Density:
No information found.
pH:
No information found.
% Volatiles by volume @ 21C (70F):
0
Boiling Point:
150C (302F) Decomposes.
Melting Point:
163C (325F)
Vapor Density (Air=1):
No information found.
Vapor Pressure (mm Hg):
No information found.
Evaporation Rate (BuAc=1):
No information found.
Stability:
Reasonably stable at room temperature under ordinary conditions of use and storage. At temperatures of 40C to 50C, slight decomposition can occur gradually as evidenced by strong organic odor and darkening of color. Advanced decomposition results in oily, dark appearing substance, strong organic odor and formation of some liquids. In a dry state, the free acid form can detonate. Acidic solutions of this material should not be kept or heated.
Hazardous Decomposition Products:
Major decomposition begins at about 150C. The decomposition is exothermic with formation of ammonia, oxides of nitrogen and condensed anilines.
Hazardous Polymerization:
Will not occur.
Incompatibilities:
Strong oxidizing agents, strong acids, strong bases.
Conditions to Avoid:
Incompatibles.
Oral rat LD50:199 mg/kg
Irritation skin rabbit (standard Draize): 20 mg/24H moderate Investigated as a tumorigen and mutagen.
--------\Cancer Lists\------------------------------------------------------
---NTP Carcinogen---
Ingredient Known Anticipated IARC Category
------------------------------------ ----- ----------- -------------
Cupferron (135-20-6) No Yes None
Environmental Fate:
No information found.
Environmental Toxicity:
No information found.
Whatever cannot be saved for recovery or recycling should be managed in an appropriate and approved waste facility. Although not a listed RCRA hazardous waste, this material may exhibit one or more characteristics of a hazardous waste and require appropriate analysis to determine specific disposal requirements. Processing, use or contamination of this product may change the waste management options. State and local disposal regulations may differ from federal disposal regulations. Dispose of container and unused contents in accordance with federal, state and local requirements.
Not regulated.
--------\Chemical Inventory Status - Part 1\---------------------------------
Ingredient TSCA EC Japan Australia
----------------------------------------------- ---- --- ----- ---------
Cupferron (135-20-6) Yes Yes Yes Yes
--------\Chemical Inventory Status - Part 2\---------------------------------
--Canada--
Ingredient Korea DSL NDSL Phil.
----------------------------------------------- ----- --- ---- -----
Cupferron (135-20-6) Yes Yes No Yes
--------\Federal, State & International Regulations - Part 1\----------------
-SARA 302- ------SARA 313------
Ingredient RQ TPQ List Chemical Catg.
----------------------------------------- --- ----- ---- --------------
Cupferron (135-20-6) No No Yes No
--------\Federal, State & International Regulations - Part 2\----------------
-RCRA- -TSCA-
Ingredient CERCLA 261.33 8(d)
----------------------------------------- ------ ------ ------
Cupferron (135-20-6) No No No
Chemical Weapons Convention: No TSCA 12(b): No CDTA: No
SARA 311/312: Acute: Yes Chronic: Yes Fire: No Pressure: No
Reactivity: No (Pure / Solid)
WARNING:
THIS PRODUCT CONTAINS A CHEMICAL(S) KNOWN TO THE STATE OF CALIFORNIA TO CAUSE CANCER.
Australian Hazchem Code: None allocated.
Poison Schedule: None allocated.
WHMIS:
This MSDS has been prepared according to the hazard criteria of the Controlled Products Regulations (CPR) and the MSDS contains all of the information required by the CPR.
NFPA Ratings: Health: 2 Flammability: 1 Reactivity: 1
Label Hazard Warning:
WARNING! POSSIBLE CANCER HAZARD. MAY CAUSE CANCER BASED ON ANIMAL DATA. Risk of cancer depends on duration and level of exposure. CAUSES IRRITATION TO SKIN, EYES AND RESPIRATORY TRACT. HARMFUL IF SWALLOWED, INHALED OR ABSORBED THROUGH SKIN.
Label Precautions:
Do not get in eyes, on skin, or on clothing.
Do not breathe mist.
Keep container closed.
Use only with adequate ventilation.
Wash thoroughly after handling.
Label First Aid:
In case of contact, immediately flush eyes or skin with plenty of water for at least 15 minutes. Remove contaminated clothing and shoes. Wash clothing before reuse. If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. If swallowed, induce vomiting immediately as directed by medical personnel. Never give anything by mouth to an unconscious person. In all cases, get medical attention.
Product Use:
Laboratory Reagent.
Revision Information:
No Changes.
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Prepared by: Environmental Health & Safety
Phone Number: (314) 654-1600 (U.S.A.)