MSDS Number: B2329 * * * * * Effective Date: 05/17/07 * * * * * Supercedes: 05/07/07 BIOTIN


BIOTIN


1. Product Identification

Synonyms: Hexahydro-2-oxo-1H-thieno [3,4-d] imidazole-4-pentanoic acid; (+)-Biotin; Vitamin B7
CAS No.: 58-85-5
Molecular Weight: 244,32
Chemical Formula: C10H16N2O3S
Product Codes: C272

2. Composition/Information on Ingredients


  Ingredient                                CAS No         Percent        Hazardous                                  
  ---------------------------------------   ------------   ------------   ---------   
 
  Biotin                                    58-85-5          90 - 100%       Yes                                                                    
 

3. Hazards Identification

Emergency Overview
--------------------------
As part of good industrial and personal hygiene and safety procedure, avoid all unnecessary exposure to the chemical substance and ensure prompt removal from skin, eyes and clothing.

SAF-T-DATA(tm) Ratings (Provided here for your convenience)
-----------------------------------------------------------------------------------------------------------
Health Rating: 0 - None
Flammability Rating: 1 - Slight
Reactivity Rating: 1 - Slight
Contact Rating: 0 - None
Lab Protective Equip: GOGGLES; LAB COAT; PROPER GLOVES
Storage Color Code: Green (General Storage)
-----------------------------------------------------------------------------------------------------------

Potential Health Effects
----------------------------------

Inhalation:
No adverse health effects expected from inhalation.
Ingestion:
Large doses may cause gastro-intestinal upset.
Skin Contact:
No adverse effects expected.
Eye Contact:
No adverse effects expected.
Chronic Exposure:
No information found.
Aggravation of Pre-existing Conditions:
No information found.

4. First Aid Measures

Inhalation:
Not expected to require first aid measures. Remove to fresh air. Get medical attention for any breathing difficulty.
Ingestion:
If large amounts were swallowed, give water to drink and get medical advice.
Skin Contact:
Wash exposed area with soap and water. Get medical advice if irritation develops.
Eye Contact:
Wash thoroughly with running water. Get medical advice if irritation develops.

5. Fire Fighting Measures

Fire:
As with most organic solids, fire is possible at elevated temperatures or by contact with an ignition source.
Explosion:
Fine dust dispersed in air in sufficient concentrations, and in the presence of an ignition source is a potential dust explosion hazard.
Fire Extinguishing Media:
Water spray, dry chemical, alcohol foam, or carbon dioxide.
Special Information:
In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full facepiece operated in the pressure demand or other positive pressure mode.

6. Accidental Release Measures

Ventilate area of leak or spill. Wear appropriate personal protective equipment as specified in Section 8. Spills: Sweep up and containerize for reclamation or disposal. Vacuuming or wet sweeping may be used to avoid dust dispersal. Remove all sources of ignition. Ventilate area of leak or spill. Wear appropriate personal protective equipment as specified in Section 8. Spills: Clean up spills in a manner that does not disperse dust into the air. Use non-sparking tools and equipment. Reduce airborne dust and prevent scattering by moistening with water. Pick up spill for recovery or disposal and place in a closed container.



7. Handling and Storage

Keep in a tightly closed container, stored in a cool, dry, ventilated area. Protect against physical damage. Containers of this material may be hazardous when empty since they retain product residues (dust, solids); observe all warnings and precautions listed for the product.

8. Exposure Controls/Personal Protection

Airborne Exposure Limits:
None established.
Ventilation System:
Not expected to require any special ventilation.
Personal Respirators (NIOSH Approved):
Not expected to require personal respirator usage.
Skin Protection:
Wear protective gloves and clean body-covering clothing.
Eye Protection:
Use chemical safety goggles.

9. Physical and Chemical Properties

Appearance:
White powder.
Odor:
No information found.
Solubility:
Very slightly soluble in water and ethanol.
Specific Gravity:
No information found.
pH:
No information found.
% Volatiles by volume @ 21C (70F):
0
Boiling Point:
No information found.
Melting Point:
232C (450F) Decomposes.
Vapor Density (Air=1):
No information found.
Vapor Pressure (mm Hg):
No information found.
Evaporation Rate (BuAc=1):
No information found.

10. Stability and Reactivity

Stability:
Stable under ordinary conditions of use and storage.
Hazardous Decomposition Products:
Burning may produce carbon monoxide, carbon dioxide, sulfur oxides, and nitrogen oxides.
Hazardous Polymerization:
Will not occur.
Incompatibilities:
Nitrous acid, oxidizing agents, formaldehyde, chloramine-T, strong acid or alkali.
Conditions to Avoid:
Heat, sunlight, ultraviolet light, and incompatibles.

11. Toxicological Information


No LD50/LC50 information found relating to normal routes of occupational exposure. Investigated as a reproductive effector.
  --------\Cancer Lists\------------------------------------------------------
                                         ---NTP Carcinogen---
  Ingredient                             Known    Anticipated    IARC Category
  ------------------------------------   -----    -----------    -------------
  Biotin (58-85-5)                        No          No            None

12. Ecological Information

Environmental Fate:
No information found.
Environmental Toxicity:
No information found.

13. Disposal Considerations

Whatever cannot be saved for recovery or recycling should be managed in an appropriate and approved waste disposal facility. Processing, use or contamination of this product may change the waste management options. State and local disposal regulations may differ from federal disposal regulations. Dispose of container and unused contents in accordance with federal, state and local requirements.

14. Transport Information

Not regulated.

15. Regulatory Information

  --------\Chemical Inventory Status - Part 1\---------------------------------
  Ingredient                                       TSCA  EC   Japan  Australia
  -----------------------------------------------  ----  ---  -----  ---------
  Biotin (58-85-5)                                  Yes  Yes   Yes      Yes                                      
 
  --------\Chemical Inventory Status - Part 2\---------------------------------
                                                          --Canada--
  Ingredient                                       Korea  DSL   NDSL  Phil.
  -----------------------------------------------  -----  ---   ----  -----
  Biotin (58-85-5)                                  Yes   Yes   No     Yes                                                                     
 
  --------\Federal, State & International Regulations - Part 1\----------------
                                             -SARA 302-    ------SARA 313------
  Ingredient                                 RQ    TPQ     List  Chemical Catg.
  -----------------------------------------  ---   -----   ----  --------------
  Biotin (58-85-5)                           No    No      No         No
 
  --------\Federal, State & International Regulations - Part 2\----------------
                                                        -RCRA-    -TSCA-
  Ingredient                                 CERCLA     261.33     8(d) 
  -----------------------------------------  ------     ------    ------
  Biotin (58-85-5)                           No         No         No                                                               
 
 
Chemical Weapons Convention:  No     TSCA 12(b):  No     CDTA:  No
SARA 311/312:  Acute: No       Chronic: No   Fire: No  Pressure: No
Reactivity: No          (Pure / Solid) 


Australian Hazchem Code: None allocated.
Poison Schedule: None allocated.
WHMIS:
This MSDS has been prepared according to the hazard criteria of the Controlled Products Regulations (CPR) and the MSDS contains all of the information required by the CPR.

16. Other Information

NFPA Ratings: Health: 0 Flammability: 1 Reactivity: 0
Label Hazard Warning:
As part of good industrial and personal hygiene and safety procedure, avoid all unnecessary exposure to the chemical substance and ensure prompt removal from skin, eyes and clothing.
Label Precautions:
None.
Label First Aid:
Not applicable.
Product Use:
Laboratory Reagent.
Revision Information:
MSDS Section(s) changed since last revision of document include: 3.
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Prepared by: Environmental Health & Safety
Phone Number: (314) 654-1600 (U.S.A.)