MSDS Number: E0925 * * * * * Effective Date: 01/01/96 Epichlorohydrin


Epichlorohydrin


1. Product Identification

Synonyms: Chloromethyloxirane; (alpha)-Epichlorohydrin; Chloropropylene oxide; Propane, 1-chloro-2,3-epoxy
CAS No.: 106-89-8
Molecular Weight: 92.53
Chemical Formula: ClCH2C2H3O
Product Codes: L099

2. Composition/Information on Ingredients


 
  Ingredient                                CAS No         Percent        Hazardous                                  
  ---------------------------------------   ------------   ------------   ---------   
 
  Epichlorohydrin                           106-89-8         90 - 100%       Yes                                                                    
 

3. Hazards Identification

Emergency Overview
--------------------------
DANGER! CAUSES BURNS TO ANY AREA OF CONTACT. HARMFUL IF SWALLOWED, INHALED OR ABSORBED THROUGH SKIN. AFFECTS LUNG, LIVER, KIDNEYS AND REPRODUCTIVE SYSTEM. VAPOR IS SEVERELY IRRITATING TO EYES AND RESPIRATORY TRACT. FLAMMABLE LIQUID AND VAPOR. MAY VIOLENTLY POLYMERIZE AND RESULT IN FIRE AND EXPLOSION. WATER REACTIVE. MAY CAUSE ALLERGIC SKIN OR RESPIRATORY REACTION. SUSPECT CANCER HAZARD. MAY CAUSE CANCER. Risk of cancer depends on level and duration of exposure. POSSIBLE BIRTH DEFECT HAZARD. MAY CAUSE BIRTH DEFECTS BASED ON ANIMAL DATA.

J.T. Baker SAF-T-DATA(tm) Ratings (Provided here for your convenience)
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Health Rating: 3 - Severe (Life)
Flammability Rating: 3 - Severe (Flammable)
Reactivity Rating: 1 - Slight
Contact Rating: 3 - Severe (Life)
Lab Protective Equip: GOGGLES & SHIELD; LAB COAT & APRON; VENT HOOD; PROPER GLOVES; CLASS B EXTINGUISHER
Storage Color Code: Red (Flammable)
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Potential Health Effects
----------------------------------

Inhalation:
Inhalation can cause severe irritation of mucous membranes and upper respiratory tract. Symptoms may include burning sensation, coughing, wheezing, laryngitis, shortness of breath, headache, nausea and vomiting. High concentrations may cause lung damage. May cause allergic reaction in sensitive individuals. Inhalation of higher concentrations may affect central nervous system and be fatal.
Ingestion:
Corrosive. Swallowing can cause severe burns of the mouth, throat, and stomach, leading to death. Can cause sore throat, vomiting, diarrhea. May affect central nervous system.
Skin Contact:
Corrosive. Symptoms of redness, pain, and severe burn can occur. Effects may be delayed. May be absorbed through the skin with possible systemic effects.
Eye Contact:
Corrosive! Vapors are severely irritating and may cause damage to the eyes. Contact may cause severe burns and permanent eye damage. Effects may be delayed.
Chronic Exposure:
Prolonged or repeated exposure may cause lung damage, kidney damage, liver damage, blood effects, skin sensitization and respiratory tract sensitization. A suspect human carcinogen. Reports have shown that exposure to epichlorohydrin by oral, inhalation, and subcutaneous routes impaired male fertility and/or spermatogenesis. Animal studies, at experimentally high levels, show that epichlorohydrin may have fetotoxic effects. Separate studies indicate that this material is also a mutagen.
Aggravation of Pre-existing Conditions:
Persons with pre-existing skin disorders or eye problems, or impaired liver, kidney or respiratory function may be more susceptible to the effects of the substance.

4. First Aid Measures

Inhalation:
Remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention immediately.
Ingestion:
If swallowed, DO NOT INDUCE VOMITING. Give large quantities of water. Never give anything by mouth to an unconscious person. Get medical attention immediately.
Skin Contact:
Wipe off excess material from skin then immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Get medical attention immediately. Wash clothing before reuse. Thoroughly clean shoes before reuse.
Eye Contact:
Immediately flush eyes with plenty of water for at least 15 minutes, lifting lower and upper eyelids occasionally. Get medical attention immediately.

Note to Physician:
Exposure may cause kidney or liver failure. Monitor serial liver enzymes for several days after exposure. Observe urine for casts, proteins and abnormal cells.

5. Fire Fighting Measures

Fire:
Flash point: 31C (88F) CC
Autoignition temperature: 416C (781F)
Flammable limits in air % by volume:
lel: 3.8; uel: 21.0
Flammable Liquid and Vapor! Contact with strong oxidizers may cause fire.
Explosion:
Above flash point, vapor-air mixtures are explosive within flammable limits noted above. Sealed containers may rupture when heated. Vapors can flow along surfaces to distant ignition source and flash back. Sensitive to static discharge.
Fire Extinguishing Media:
Alcohol foam. Water may be used to cool containers and to knock down vapors in a fire situation. Do not use water on material itself or allow water to get inside container. Use water with caution as material reacts with water.
Special Information:
In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full facepiece operated in the pressure demand or other positive pressure mode. Combustion by-products include phosgene and hydrogen chloride gases. Structural firefighter's protective clothing is ineffective for fires involving this material. Stay away from sealed containers.

6. Accidental Release Measures

Ventilate area of leak or spill. Remove all sources of ignition. Wear appropriate personal protective equipment as specified in Section 8. Isolate hazard area. Keep unnecessary and unprotected personnel from entering. Contain and recover liquid when possible. Use non-sparking tools and equipment. Collect liquid in an appropriate container or absorb with an inert material (e. g., vermiculite, dry sand, earth), and place in a chemical waste container. Do not use combustible materials, such as saw dust. Do not flush to sewer! If a leak or spill has not ignited, use water spray to disperse the vapors and to protect personnel attempting to stop leak. Use water with caution as material may react dangerously with water. US Regulations (CERCLA) require reporting spills and releases to soil, water and air in excess of reportable quantities. The toll free number for the US Coast Guard National Response Center is (800) 424-8802.


J. T. Baker SOLUSORB® solvent adsorbent is recommended for spills of this product.

7. Handling and Storage

Protect against physical damage. Store in a cool, dry well-ventilated location, away from any area where the fire hazard may be acute. Outside or detached storage is preferred. Separate from incompatibles. Containers should be bonded and grounded for transfers to avoid static sparks. Storage and use areas should be No Smoking areas. Use non-sparking type tools and equipment, including explosion proof ventilation. Wear special protective equipment (Sec. 8) for maintenance break-in or where exposures may exceed established exposure levels. Wash hands, face, forearms and neck when exiting restricted areas. Shower, dispose of outer clothing, change to clean garments at the end of the day. Avoid cross-contamination of street clothes. Wash hands before eating and do not eat, drink, or smoke in workplace. Training should be provided to anyone working with or near this material. Training should cover potential health effects and proper handling techniques. Keep away from water. Containers of this material may be hazardous when empty since they retain product residues (vapors, liquid); observe all warnings and precautions listed for the product.

8. Exposure Controls/Personal Protection

Airborne Exposure Limits:
- OSHA Permissible Exposure Limit (PEL):
5 ppm (TWA), skin.

- ACGIH Threshold Limit Value (TLV):
0.5 ppm (TWA), skin A3 - Animal Carcinogen
Ventilation System:
A system of local and/or general exhaust is recommended to keep employee exposures below the Airborne Exposure Limits. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area. Please refer to the ACGIH document, Industrial Ventilation, A Manual of Recommended Practices, most recent edition, for details. Use explosion-proof equipment.
Personal Respirators (NIOSH Approved):
If the exposure limit is exceeded and engineering controls are not feasible, wear a supplied air, full-facepiece respirator, airlined hood, or full-facepiece self-contained breathing apparatus. Breathing air quality must meet the requirements of the OSHA respiratory protection standard (29CFR1910.134). This substance has questionable warning properties.
Skin Protection:
Wear impervious protective clothing, including boots, gloves, lab coat, apron or coveralls, as appropriate, to prevent skin contact. Do not use polyethylene or polyvinyl chloride gloves or aprons. Liquid epichlorohydrin in continuous contact with heavy rubber may penetrate in as little as 15 minutes. Epichlorohydrin can penetrate leather.
Eye Protection:
Use chemical safety goggles and/or a full face shield where splashing is possible. Maintain eye wash fountain and quick-drench facilities in work area.

9. Physical and Chemical Properties

Appearance:
Colorless liquid.
Odor:
Chloroform-like odor.
Solubility:
Moderate (1-10%)
Specific Gravity:
1.18 @ 20C/4C
pH:
No information found.
% Volatiles by volume @ 21C (70F):
100
Boiling Point:
116C (241F)
Melting Point:
-48C (-54F)
Vapor Density (Air=1):
3.3
Vapor Pressure (mm Hg):
12.5 @ 20C (68F)
Evaporation Rate (BuAc=1):
No information found.

10. Stability and Reactivity

Stability:
Unstable.
Hazardous Decomposition Products:
May produce carbon monoxide, carbon dioxide, hydrogen chloride and phosgene when heated to decomposition.
Hazardous Polymerization:
Hazardous exothermic polymerization can occur in the presence of strong acids, caustic alkalies, aluminum, aluminum chloride, iron (III) chloride, zinc, and curing agents such as ethylenediamine.
Incompatibilities:
Epichlorohydrin can react violently with compounds carrying an active hydrogen atom, including water. This material is incompatible with strong oxidizers, strong acids, caustric, mercaptans, zinc, aluminum, and chlorides of iron. Epichlorohydrin ignites on contact with potassium tert-butoxide. Reaction with trichloroethylene forms the explosive dichloroacetylene. A violent reaction occurs with isopropylamine or aniline.
Conditions to Avoid:
Heat, flames, ignition sources and incompatibles.

11. Toxicological Information

Toxicological Data:
Oral rat LD50: 90 mg/kg; inhalation rat, LC50: 250 ppm/8-hour; skin rabbit, LD50: 515 mg/kg. Investigated as a tumorigen, mutagen, reproductive effector.

Reproductive Toxicity:
See Chronic Health Hazards.

 
  --------\Cancer Lists\------------------------------------------------------
                                         ---NTP Carcinogen---
  Ingredient                             Known    Anticipated    IARC Category
  ------------------------------------   -----    -----------    -------------
  Epichlorohydrin (106-89-8)              No          Yes            2A

12. Ecological Information

Environmental Fate:
When released into the soil, this material may biodegrade to a moderate extent. When released into the soil, this material is expected to leach into groundwater. When released into the soil, this material is expected to quickly evaporate. When released into water, this material may biodegrade to a moderate extent. When released to water, this material is expected to quickly evaporate. This material has an estimated bioconcentration factor (BCF) of less than 100. This material is not expected to significantly bioaccumulate. When released into the air, this material is expected to be readily degraded by reaction with photochemically produced hydroxyl radicals. When released into the air, this material is expected to have a half-life between 1 and 10 days.
Environmental Toxicity:
This material is expected to be slightly toxic to aquatic life. The LC50/96-hour values for fish are between 10 and 100 mg/l.

13. Disposal Considerations

Whatever cannot be saved for recovery or recycling should be handled as hazardous waste and sent to a RCRA approved waste facility. Processing, use or contamination of this product may change the waste management options. State and local disposal regulations may differ from federal disposal regulations. Dispose of container and unused contents in accordance with federal, state and local requirements.

14. Transport Information

Domestic (Land, D.O.T.)
-----------------------
Proper Shipping Name: EPICHLOROHYDRIN
Hazard Class: 6.1, 3
UN/NA: UN2023
Packing Group: II
Information reported for product/size: 2.5L

International (Water, I.M.O.)
-----------------------------
Proper Shipping Name: EPICHLOROHYDRIN
Hazard Class: 6.1, 3
UN/NA: UN2023
Packing Group: II
Information reported for product/size: 2.5L

International (Air, I.C.A.O.)
-----------------------------
Proper Shipping Name: EPICHLOROHYDRIN
Hazard Class: 6.1, 3
UN/NA: UN2023
Packing Group: II
Information reported for product/size: 2.5L

15. Regulatory Information

 
  --------\Chemical Inventory Status - Part 1\---------------------------------
  Ingredient                                       TSCA  EC   Japan  Australia
  -----------------------------------------------  ----  ---  -----  ---------
  Epichlorohydrin (106-89-8)                        Yes  Yes   Yes      Yes                                      
 
  --------\Chemical Inventory Status - Part 2\---------------------------------
                                                          --Canada--
  Ingredient                                       Korea  DSL   NDSL  Phil.
  -----------------------------------------------  -----  ---   ----  -----
  Epichlorohydrin (106-89-8)                        Yes   Yes   No     Yes       
 
  --------\Federal, State & International Regulations - Part 1\----------------
                                             -SARA 302-    ------SARA 313------
  Ingredient                                 RQ    TPQ     List  Chemical Catg.
  -----------------------------------------  ---   -----   ----  --------------
  Epichlorohydrin (106-89-8)                 100   1000    Yes        No
 
  --------\Federal, State & International Regulations - Part 2\----------------
                                                        -RCRA-    -TSCA-
  Ingredient                                 CERCLA     261.33     8(d) 
  -----------------------------------------  ------     ------    ------
  Epichlorohydrin (106-89-8)                 100        U041       No     
 
 
Chemical Weapons Convention:  No     TSCA 12(b):  No     CDTA:  No
SARA 311/312:  Acute: Yes      Chronic: Yes  Fire: Yes Pressure: No
Reactivity: Yes         (Mixture / Liquid)
WARNING:
THIS PRODUCT CONTAINS CHEMICALS KNOWN TO THE STATE OF CALIFORNIA TO CAUSE CANCER AND BIRTH DEFECTS OR OTHER REPRODUCTIVE HARM.

Australian Hazchem Code: 2W
Poison Schedule: None allocated.
WHMIS:
This MSDS has been prepared according to the hazard criteria of the Controlled Products Regulations (CPR) and the MSDS contains all of the information required by the CPR.

16. Other Information

NFPA Ratings: Health: 3 Flammability: 3 Reactivity: 2
Label Hazard Warning:
DANGER! CAUSES BURNS TO ANY AREA OF CONTACT. HARMFUL IF SWALLOWED, INHALED OR ABSORBED THROUGH SKIN. AFFECTS LUNG, LIVER, KIDNEYS AND REPRODUCTIVE SYSTEM. VAPOR IS SEVERELY IRRITATING TO EYES AND RESPIRATORY TRACT. FLAMMABLE LIQUID AND VAPOR. MAY VIOLENTLY POLYMERIZE AND RESULT IN FIRE AND EXPLOSION. WATER REACTIVE. MAY CAUSE ALLERGIC SKIN OR RESPIRATORY REACTION. SUSPECT CANCER HAZARD. MAY CAUSE CANCER. Risk of cancer depends on level and duration of exposure. POSSIBLE BIRTH DEFECT HAZARD. MAY CAUSE BIRTH DEFECTS BASED ON ANIMAL DATA.
Label Precautions:
Keep away from heat, sparks and flame.
Do not get in eyes, on skin, or on clothing.
Do not breathe vapor.
Keep container closed.
Use only with adequate ventilation.
Wash thoroughly after handling.
Do not contact with water.
Label First Aid:
In case of contact, wipe off excess material from skin then immediately flush eyes or skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. If swallowed, DO NOT INDUCE VOMITING. Give large quantities of water. Never give anything by mouth to an unconscious person. In all cases get medical attention immediately.
Product Use:
Laboratory Reagent.
Revision Information:
MSDS Section(s) changed since last revision of document include: 14.
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Prepared by: Environmental Health & Safety
Phone Number: (314) 654-1600 (U.S.A.)