Ethyl Benzene For Synthesis MSDS

Section 1: Chemical Product and Company Identification

Product Name: Ethyl Benzene For Synthesis

Catalog Codes: SLE2044

CAS#: 100-41-4

RTECS: DA0700000

TSCA: TSCA 8(b) inventory: Ethyl Benzene For Synthesis

CI#: Not available.

Synonym: Ethyl Benzene; Ethylbenzol; Phenylethane

Chemical Name: Ethylbenzene

Chemical Formula: C8H10

Section 2: Composition and Information on Ingredients

Composition:

Name CAS # % by Weight

Ethylbenzene 100-41-4 100

Toxicological Data on Ingredients: Ethylbenzene: ORAL (LD50): Acute: 3500 mg/kg [Rat].

Section 3: Hazards Identification

Potential Acute Health Effects:

Hazardous in case of eye contact (irritant), of ingestion, of inhalation. Slightly hazardous in case of skin contact

(irritant, permeator).

Potential Chronic Health Effects:

Slightly hazardous in case of skin contact (irritant, sensitizer).

CARCINOGENIC EFFECTS: Classified 2B (Possible for human.) by IARC.

MUTAGENIC EFFECTS: Mutagenic for mammalian somatic cells. Mutagenic for bacteria and/or yeast.

TERATOGENIC EFFECTS: Not available.

DEVELOPMENTAL TOXICITY: Not available.

The substance may be toxic to central nervous system (CNS).

Repeated or prolonged exposure to the substance can produce target organs damage.

Section 4: First Aid Measures

Eye Contact:

Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at

least 15 minutes. Cold water may be used. WARM water MUST be used. Get medical attention.

Skin Contact: Wash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation develops.

Serious Skin Contact: Not available.

Inhalation:

If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get

medical attention.

Serious Inhalation:

Evacuate the victim to a safe area as soon as possible. Loosen tight clothing such as a collar, tie, belt or

waistband. If breathing is difficult, administer oxygen. If the victim is not breathing, perform mouth-to-mouth

resuscitation. WARNING: It may be hazardous to the person providing aid to give mouth-to-mouth resuscitation

when the inhaled material is toxic, infectious or corrosive. Seek medical attention.

Ingestion:

Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an

unconscious person. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical attention if

symptoms appear.

Serious Ingestion: Not available.

Section 5: Fire and Explosion Data

Flammability of the Product: Flammable.

Auto-Ignition Temperature: 432°C (809.6°F)

Flash Points:

CLOSED CUP: 15°C (59°F). (Tagliabue.) OPEN CUP: 26.667°C (80°F) (Cleveland) (CHRIS, 2001)

CLOSED CUP: 12.8 C (55 F) (Bingham et al, 2001; NIOSH, 2001)

CLOSED CUP: 21 C (70 F) (NFPA)

Flammable Limits: LOWER: 0.8% - 1.6%UPPER: 6.7% - 7%

Products of Combustion: These products are carbon oxides (CO, CO2).

Fire Hazards in Presence of Various Substances: Highly flammable in presence of open flames and sparks, of heat.

Explosion Hazards in Presence of Various Substances:

Risks of explosion of the product in presence of mechanical impact: Not available.

Risks of explosion of the product in presence of static discharge: Not available.

Slightly explosive in presence of heat.

Fire Fighting Media and Instructions:

Flammable liquid, soluble or dispersed in water.

SMALL FIRE: Use DRY chemical powder.

LARGE FIRE: Use alcohol foam, water spray or fog.

Special Remarks on Fire Hazards:

Vapor may travel considerable distance to source of ignition and flash back. Vapors may form explosive mixtures

with air. When heated to decomposition it emits acrid smoke and irritating fumes.

Special Remarks on Explosion Hazards: Vapors may form explosive mixtures in air.

Section 6: Accidental Release Measures

Small Spill: Absorb with an inert material and put the spilled material in an appropriate waste disposal.

Large Spill:

Flammable liquid.

Keep away from heat. Keep away from sources of ignition. Stop leak if without risk. Absorb with DRY earth,

sand or other non-combustible material. Do not touch spilled material. Prevent entry into sewers, basements or

confined areas; dike if needed. Be careful that the product is not present at a concentration level above TLV.

Check TLV on the MSDS and with local authorities.

Section 7: Handling and Storage

Precautions:

Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do not

ingest. Do not breathe gas/fumes/ vapor/spray. Avoid contact with eyes. Wear suitable protective clothing. In

case of insufficient ventilation, wear suitable respiratory equipment. If ingested, seek medical advice immediately

and show the container or the label. Keep away from incompatibles such as oxidizing agents.

Storage:

Store in a segregated and approved area. Keep container in a cool, well-ventilated area. Keep container tightly

closed and sealed until ready for use. Avoid all possible sources of ignition (spark or flame). Sensitive to light.

Store in light-resistant containers.

Section 8: Exposure Controls/Personal Protection

Engineering Controls:

Provide exhaust ventilation or other engineering controls to keep the airborne concentrations of vapors below their

respective threshold limit value. Ensure that eyewash stations and safety showers are proximal to the

work-station location.

Personal Protection:

Splash goggles. Lab coat. Vapor respirator. Be sure to use an approved/certified respirator or equivalent.

Gloves.

Personal Protection in Case of a Large Spill:

Splash goggles. Full suit. Vapor respirator. Boots. Gloves. A self contained breathing apparatus should be

used to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist

BEFORE handling this product.

Exposure Limits:

TWA: 100 STEL: 125 (ppm) from OSHA (PEL) [United States]

TWA: 435 STEL: 545 from OSHA (PEL) [United States]

TWA: 435 STEL: 545 (mg/m3) from NIOSH [United States]

TWA: 100 STEL: 125 (ppm) from NIOSH [United States]

TWA: 100 STEL: 125 (ppm) from ACGIH (TLV) [United States]

TWA: 100 STEL: 125 (ppm) [United Kingdom (UK)]

TWA: 100 STEL: 125 (ppm) [Belgium]

TWA: 100 STEL: 125 (ppm) [Finland]

TWA: 50 (ppm) [Norway]

Consult local authorities for acceptable exposure limits.

Section 9: Physical and Chemical Properties

Physical state and appearance: Liquid.

Odor: Sweetish. Gasoline-like. Aromatic.

Taste: Not available.

Molecular Weight: 106.16 g/mole

Color: Colorless.

pH (1% soln/water): Not available.

Boiling Point: 136°C (276.8°F)

Melting Point: -94.9 (-138.8°F)

Critical Temperature: 617.15°C (1142.9°F)

Specific Gravity: 0.867 (Water = 1)

Vapor Pressure: 0.9 kPa (@ 20°C)

Vapor Density: 3.66 (Air = 1)

Volatility: 100% (v/v).

Odor Threshold: 140 ppm

Water/Oil Dist. Coeff.: The product is more soluble in oil; log(oil/water) = 3.1

Ionicity (in Water): Not available.

Dispersion Properties: See solubility in water, diethyl ether.

Solubility:

Easily soluble in diethyl ether.

Very slightly soluble in cold water or practically insoluble in water.

Soluble in all proportions in Ethyl alcohol.

Soluble in Carbon tetrachloride, Benzene.

Insoluble in Ammonia.

Slightly soluble in Chloroform.

Solubility in Water: 169 mg/l @ 25 deg. C.; 0.014 g/100 ml @ 15 deg. C.

Section 10: Stability and Reactivity Data

Stability: The product is stable.

Instability Temperature: Not available.

Conditions of Instability: Heat, ingnition sources (flames, sparks, static), incompatible materials, light

Incompatibility with various substances: Reactive with oxidizing agents.

Corrosivity: Not considered to be corrosive for metals and glass.

Special Remarks on Reactivity:

Can react vigorously with oxidizing materials.

Sensitive to light.

Special Remarks on Corrosivity: Not available.

Polymerization: Will not occur.

Section 11: Toxicological Information

Routes of Entry: Absorbed through skin. Inhalation.

Toxicity to Animals: Acute oral toxicity (LD50): 3500 mg/kg [Rat].

Chronic Effects on Humans:

CARCINOGENIC EFFECTS: Classified 2B (Possible for human.) by IARC.

MUTAGENIC EFFECTS: Mutagenic for mammalian somatic cells. Mutagenic for bacteria and/or yeast.

May cause damage to the following organs: central nervous system (CNS).

Other Toxic Effects on Humans:

Hazardous in case of ingestion, of inhalation.

Slightly hazardous in case of skin contact (irritant, permeator).

Special Remarks on Toxicity to Animals:

Lethal Dose/Conc 50% Kill:

LD50 [Rabbit] - Route: Skin; Dose: 17800 ul/kg

Lowest Published Lethal Dose/Conc:

LDL[Rat] - Route: Inhalation (vapor); Dose: 4000 ppm/4 H

Special Remarks on Chronic Effects on Humans:

May cause adverse reproductive effects and birth defects (teratogenic) based on animal test data.

May cause cancer based on animals data. IARC evidence for carcinogenicity in animals is sufficient. IARC

evidence of carcinogenicity in humans inadequate.

May affect genetic material (mutagenic).

Special Remarks on other Toxic Effects on Humans:

Acute Potential Health Effects:

Skin: Can cause mild skin irritation. It can be absorbed through intact skin.

Eyes: Contact with vapor or liquid can cause severe eye irritation depending on concentration. It may also cause

conjunctivitis. At a vapor exposure level of 85 - 200 ppm , it is mildly and transiently irritating to the eyes; 1000

ppm causes further irritation and tearing; 2000 ppm results in immediate and severe irritation and tearing; 5,000

ppm is intolerable (ACGIH, 1991; Clayton and Clayton, 1994). Standard draize test for eye irritation using 500 mg

resulted in severe irritation (RTECS)

Inhalation: Exposure to high concentrations can cause nasal, mucous membrane and respiratory tract irritation

and can also result in chest constriction and, trouble breathing, respiratory failure, and even death. It can also

affect behavior/Central Nervous System. The effective dose for CNS depression in experimental animals was

10,000 ppm (ACGIH, 1991). Symptoms of CNS depression include headache, nausea, weakness, dizziness,

vertigo, irritability, fatigue, lightheadedness, sleepiness, tremor, loss of coordination, judgement and

conciousness, coma, and death. It can also cause pulmonary edema. Inhalation of 85 ppm can produce fatigue,

insomnia, headache, and mild irritation of the respiratory tract (Haley & Berndt, 1987).

Ingestion: Do not drink, pipet or siphon by mouth. May cause gastroinestinal/digestive tract irritation with

Abdominal pain, nausea, vomiting. Ethylbenzene is a pulmonary aspiration hazard. Pulmonary aspiration of even

small amounts of the liquid may cause fatal pneumonitis. It may also affect behavior/central nervous system with

Section 12: Ecological Information

Ecotoxicity:

Ecotoxicity in water (LC50): 14 mg/l 96 hours [Fish (Trout)] (static). 12.1 mg/l 96 hours [Fish (Fathead Minnow)]

(flow-through)]. 150 mg/l 96 hours [Fish (Blue Gill/Sunfish)] (static). 275 mg/l 96 hours [Fish (Sheepshead

Minnow)]. 42.3 mg/l 96 hours [Fish (Fathead Minnow)](soft water). 87.6mg/l 96 hours [Shrimp].

BOD5 and COD: Not available.

Products of Biodegradation:

Possibly hazardous short term degradation products are not likely. However, long term degradation products may

arise.

Toxicity of the Products of Biodegradation: The products of degradation are less toxic than the product itself.

Special Remarks on the Products of Biodegradation: Not available.

Section 13: Disposal Considerations

Waste Disposal:

Waste must be disposed of in accordance with federal, state and local environmental

control regulations.

Section 14: Transport Information

DOT Classification: CLASS 3: Flammable liquid.

Identification: : Ethylbenzene UNNA: 1175 PG: II

Special Provisions for Transport: Not available.

Section 15: Other Regulatory Information

Federal and State Regulations:

Connecticut hazardous material survey.: Ethylbenzene

Illinois toxic substances disclosure to employee act: Ethylbenzene

Illinois chemical safety act: Ethylbenzene

New York release reporting list: Ethylbenzene

Rhode Island RTK hazardous substances: Ethylbenzene

Pennsylvania RTK: Ethylbenzene

Minnesota: Ethylbenzene

Massachusetts RTK: Ethylbenzene

Massachusetts spill list: Ethylbenzene

New Jersey: Ethylbenzene

New Jersey spill list: Ethylbenzene

Louisiana spill reporting: Ethylbenzene

California Director's List of Hazardous Substances: Ethylbenzene

TSCA 8(b) inventory: Ethylbenzene

TSCA 4(a) proposed test rules: Ethylbenzene

TSCA 8(d) H and S data reporting: Ethylbenzene: Effective Date: 6/19/87; Sunset Date: 6/19/97

SARA 313 toxic chemical notification and release reporting: Ethylbenzene

Other Regulations:

OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200).

EINECS: This product is on the European Inventory of Existing Commercial Chemical Substances.

Other Classifications:

WHMIS (Canada):

CLASS B-2: Flammable liquid with a flash point lower than 37.8°C (100°F).

CLASS D-2A: Material causing other toxic effects (VERY TOXIC).

CLASSE D-2B: Material causing other toxic effects (TOXIC).

DSCL (EEC):

R11- Highly flammable.

R20- Harmful by inhalation.

S16- Keep away from sources of ignition - No

smoking.

S24/25- Avoid contact with skin and eyes.

S29- Do not empty into drains.

HMIS (U.S.A.):

Health Hazard: 2

Fire Hazard: 3

Reactivity: 0

Personal Protection: h

National Fire Protection Association (U.S.A.):

Health: 2

Flammability: 3

Reactivity: 0

Specific hazard:

Protective Equipment:

Gloves.

Lab coat.

Vapor respirator. Be sure to use an

approved/certified respirator or

equivalent. Wear appropriate respirator

when ventilation is inadequate.

Splash goggles.

Section 16: Other Information

References:

-Manufacturer's Material Safety Data Sheet.

-Fire Protection Guide to Hazardous Materials, 13th ed., Nationial Fire Protection Association (NFPA)

-Registry of Toxic Effects of Chemical Substances (RTECS)

-Chemical Hazard Response Information System (CHRIS)

-Hazardous Substance Data Bank (HSDB)

-New Jersey Hazardous Substance Fact Sheet

-Ariel Global View

-Reprotext System

Other Special Considerations: Not available.

Created: 10/09/2005 05:28 PM

Last Updated: 11/06/2008 12:00 PM