Glycerol Tributyrate (for Biochemistry) (Tributyrin) MSDS

Section 1: Chemical Product and Company Identification

Product Name: Glycerol Tributyrate (for Biochemistry) (Tributyrin)

Catalog Codes: SLT2938

CAS#: 60-01-5

RTECS: ET7350000

TSCA: TSCA 8(b) inventory: Glycerol Tributyrate (for Biochemistry) (Tributyrin)

CI#: Not available.

Synonym: Glyceryl Tributyrate

Chemical Name: Tributyrin

Chemical Formula: C15-H26-O6

Section 2: Composition and Information on Ingredients

Composition:

Name CAS # % by Weight

Glycerol Tributyrate (for Biochemistry) (Tributyrin) 60-01-5 100

Toxicological Data on Ingredients: Tributyrin: ORAL (LD50): Acute: 3200 mg/kg [Rat]. 12800 mg/kg [Mouse]. VAPOR (LC):

Acute: >75 ppm 6 hours [Rat].

Section 3: Hazards Identification

Potential Acute Health Effects:

Slightly hazardous in case of skin contact (irritant, permeator), of eye contact (irritant), of ingestion, of inhalation. Severe overexposure

can result in death.

Potential Chronic Health Effects:

CARCINOGENIC EFFECTS: Not available. MUTAGENIC EFFECTS: Not available. TERATOGENIC EFFECTS: Not available.

DEVELOPMENTAL TOXICITY: Not available. Repeated exposure to a highly toxic material may produce general deterioration

of health by an accumulation in one or many human organs.

Section 4: First Aid Measures

Eye Contact:

Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15

minutes. Get medical attention if irritation occurs.

Skin Contact: Wash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation develops.

Serious Skin Contact: Not available.

Inhalation:

If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical

attention immediately.

Serious Inhalation: Not available.

Ingestion:

Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious

person. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical attention if symptoms appear.

Serious Ingestion: Not available.

Section 5: Fire and Explosion Data

Flammability of the Product: May be combustible at high temperature.

Auto-Ignition Temperature: 407.22°C (765°F)

Flash Points: CLOSED CUP: 173°C (343.4°F). OPEN CUP: 180°C (356°F).

Flammable Limits: LOWER: 0.5%

Products of Combustion: These products are carbon oxides (CO, CO2).

Fire Hazards in Presence of Various Substances:

Slightly flammable to flammable in presence of open flames and sparks. Non-flammable in presence of shocks, of heat.

Explosion Hazards in Presence of Various Substances:

Risks of explosion of the product in presence of mechanical impact: Not available. Risks of explosion of the product in

presence of static discharge: Not available.

Fire Fighting Media and Instructions:

SMALL FIRE: Use DRY chemical powder. LARGE FIRE: Use water spray, fog or foam. Do not use water jet.

Special Remarks on Fire Hazards: Not available.

Special Remarks on Explosion Hazards: Not available.

Section 6: Accidental Release Measures

Small Spill: Absorb with an inert material and put the spilled material in an appropriate waste disposal.

Large Spill:

Poisonous liquid. Stop leak if without risk. Do not get water inside container. Do not touch spilled material. Use water spray to

reduce vapors. Prevent entry into sewers, basements or confined areas; dike if needed. Eliminate all ignition sources. Call for

assistance on disposal. Finish cleaning by spreading water on the contaminated surface and allow to evacuate through the

sanitary system.

Section 7: Handling and Storage

Precautions:

Keep locked up.. Keep away from heat. Keep away from sources of ignition. Empty containers pose a fire risk, evaporate the

residue under a fume hood. Ground all equipment containing material. Do not ingest. Do not breathe gas/fumes/ vapor/spray.

Wear suitable protective clothing. If ingested, seek medical advice immediately and show the container or the label. Keep

away from incompatibles such as oxidizing agents.

Storage: Keep container tightly closed. Keep container in a cool, well-ventilated area.

Section 8: Exposure Controls/Personal Protection

Engineering Controls:

Provide exhaust ventilation or other engineering controls to keep the airborne concentrations of vapors below their respective

threshold limit value. Ensure that eyewash stations and safety showers are proximal to the work-station location.

Personal Protection:

Safety glasses. Lab coat. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Gloves.

Personal Protection in Case of a Large Spill:

Splash goggles. Full suit. Vapor respirator. Boots. Gloves. A self contained breathing apparatus should be used to avoid

inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this

product.

Exposure Limits: Not available.

Section 9: Physical and Chemical Properties

Physical state and appearance: Liquid.

Odor: Fruity, buttery

Taste: Bitter.

Molecular Weight: 302.37 g/mole

Color: Clear Colorless.

pH (1% soln/water): Not applicable.

Boiling Point: 305°C (581°F) -310 C

Melting Point: -75°C (-103°F)

Critical Temperature: Not available.

Specific Gravity: 1.035 (Water = 1)

Vapor Pressure: Not available.

Vapor Density: Not available.

Volatility: Not available.

Odor Threshold: Not available.

Water/Oil Dist. Coeff.: Not available.

Ionicity (in Water): Not available.

Dispersion Properties: See solubility in water, diethyl ether, acetone.

Solubility:

Easily soluble in diethyl ether, acetone. Very slightly soluble in hot water. Very soluble in ethanol and benzene Insoluble in

cold water.

Section 10: Stability and Reactivity Data

Stability: The product is stable.

Instability Temperature: Not available.

Conditions of Instability: Excessive heat, ignition sources, incompatible materials

Incompatibility with various substances: Reactive with oxidizing agents.

Corrosivity: Not available.

Special Remarks on Reactivity: Not available.

Special Remarks on Corrosivity: Not available.

Polymerization: Will not occur.

Section 11: Toxicological Information

Routes of Entry: Absorbed through skin. Eye contact.

Toxicity to Animals:

Acute oral toxicity (LD50): 3200 mg/kg [Rat]. Acute toxicity of the vapor (LC): >75 6 hours [Rat].

Chronic Effects on Humans: Not available.

Other Toxic Effects on Humans: Slightly hazardous in case of skin contact (irritant, permeator), of ingestion, of inhalation.

Special Remarks on Toxicity to Animals: Not available.

Special Remarks on Chronic Effects on Humans: May cause cancer based on animal test data

Special Remarks on other Toxic Effects on Humans:

Acute Potential Health Effects: Skin: May cause irritation. May be absorbed through skin. Eyes: May cause eye irritaiton.

Inhalation: May cause respiratory tract irritation. Ingestion: May cause digestive tract irritation. May affect behavior

(convulsions) and respiration (respiratory depression). It is expcected to be a low ingestion hazard. The toxicological

properties of this substance have not been fully investigated.

Section 12: Ecological Information

Ecotoxicity: Not available.

BOD5 and COD: Not available.

Products of Biodegradation:

Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise.

Toxicity of the Products of Biodegradation: The products of degradation are less toxic than the product itself.

Special Remarks on the Products of Biodegradation: Not available.

Section 13: Disposal Considerations

Waste Disposal:

Waste must be disposed of in accordance with federal, state and local environmental control regulations.

Section 14: Transport Information

DOT Classification: Not a DOT controlled material (United States).

Identification: Not applicable.

Special Provisions for Transport: Not applicable.

Section 15: Other Regulatory Information

Federal and State Regulations: TSCA 8(b) inventory: Tributyrin

Other Regulations:

OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200). EINECS: This product is on the

European Inventory of Existing Commercial Chemical Substances.

Other Classifications:

WHMIS (Canada): Not controlled under WHMIS (Canada).

DSCL (EEC):

Not available S24/25- Avoid contact with skin and eyes. S28- After contact with skin, wash immediately with plenty of [***] S37-

Wear suitable gloves. S45- In case of accident or if you feel unwell, seek medical advice immediately (show the label where

possible).

HMIS (U.S.A.):

Health Hazard: 1

Fire Hazard: 1

Reactivity: 0

Personal Protection: g

National Fire Protection Association (U.S.A.):

Health: 0

Flammability: 1

Reactivity: 0

Specific hazard:

Protective Equipment:

Gloves. Lab coat. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Safety glasses.

Section 16: Other Information

References: Not available.

Other Special Considerations: Not available.

Created: 10/11/2005 12:48 PM

Last Updated: 11/06/2008 12:00 PM