MSDS Number: P2873 * * * * * Effective Date: 11/17/99 * * * * * Supercedes: 12/08/96 p-PHENYLENEDIAMINE DIHIDROCHLORIDE


p-PHENYLENEDIAMINE DIHIDROCHLORIDE


1. Product Identification

Synonyms: 1,4-Phenylenediame dihydrochloride; 1,4-benzenediamine dihydrochloride; 4-Aminoaniline dihydrochloride
CAS No.: 624-18-0
Molecular Weight: 181.07
Chemical Formula: C6H4(NH2)2.2HCl
Product Codes: Product Codes: 6599

2. Composition/Information on Ingredients


 
  Ingredient                                CAS No         Percent        Hazardous
  ---------------------------------------   ------------   ------------   ---------
 
  p-Phenylenediamine Dihydrochloride        624-18-0         90 - 100%       Yes
 

3. Hazards Identification

Emergency Overview
--------------------------
WARNING! HARMFUL IF SWALLOWED, INHALED OR ABSORBED THROUGH SKIN. CAUSES IRRITATION TO SKIN, EYES AND RESPIRATORY TRACT. MAY CAUSE ALLERGIC SKIN OR RESPIRATORY REACTION. MAY CAUSE KIDNEY, LIVER AND BLOOD DISORDERS.

Potential Health Effects
----------------------------------

Similar health effects referenced are those of p-phenylenediamine, the parent compound.

Inhalation:
Toxic. Harmful if inhaled. Causes irritation and may sensitize the respiratory tract. Symptoms may include coughing, sneezing and shortness of breath. Can cause cyanosis (blue lips).
Ingestion:
Toxic. Harmful if swallowed. Can cause methemoglobinemia. Symptoms include vomiting, facial and neck edema which affect respiratory function, plus cyanosis.
Skin Contact:
Toxic. Causes irritation. Can be absorbed through the skin causing cyanosis. Prolonged exposure can cause contact dermatitis.
Eye Contact:
Causes irritation, redness, and pain. Corneal damage and loss of vision have been reported.
Chronic Exposure:
Lengthy exposures may affect the ability of blood to carry oxygen (methemoglobinemia), resulting in bluish discoloration of lips and tongue (cyanosis). Chronic exposure may affect kidneys and liver.
Aggravation of Pre-existing Conditions:
No information found.

4. First Aid Measures

Inhalation:
Remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention.
Ingestion:
Induce vomiting immediately as directed by medical personnel. Never give anything by mouth to an unconscious person. Get medical attention immediately.
Skin Contact:
Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Get medical attention, immediately. Wash clothing before reuse. Thoroughly clean shoes before reuse.
Eye Contact:
Immediately flush eyes with plenty of water for at least 15 minutes, lifting upper and lower eyelids occasionally. Get medical attention.

5. Fire Fighting Measures

Fire:
Not considered to be a fire hazard.
Explosion:
Not considered to be an explosion hazard.
Fire Extinguishing Media:
Use any means suitable for extinguishing surrounding fire.
Special Information:
In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full facepiece operated in the pressure demand or other positive pressure mode.

6. Accidental Release Measures

Ventilate area of leak or spill. Wear appropriate personal protective equipment as specified in Section 8. Spills: Sweep up and containerize for reclamation or disposal. Vacuuming or wet sweeping may be used to avoid dust dispersal.

7. Handling and Storage

Keep in a tightly closed container, stored in a cool, dry, ventilated area. Protect against physical damage. Isolate from incompatible substances. Containers of this material may be hazardous when empty since they retain product residues (dust, solids); observe all warnings and precautions listed for the product.

8. Exposure Controls/Personal Protection

Airborne Exposure Limits:
For Parent Compound p-Phenylenediamine:
-OSHA Permissible Exposure Limit (PEL):
100 ug/m3 (TWA) skin.

-ACGIH Threshold Limit Value (TLV):
100 ug/m3 (TWA) skin
Ventilation System:
A system of local and/or general exhaust is recommended to keep employee exposures below the Airborne Exposure Limits. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area. Please refer to the ACGIH document, Industrial Ventilation, A Manual of Recommended Practices, most recent edition, for details.
Personal Respirators (NIOSH Approved):
If the exposure limit is exceeded, a half-face respirator with an organic vapor cartridge and dust/mist filter may be worn for up to ten times the exposure limit or the maximum use concentration specified by the appropriate regulatory agency or respirator supplier, whichever is lowest. A full-face piece respirator with an organic vapor cartridge and dust/mist filter may be worn up to 50 times the exposure limit, or the maximum use concentration specified by the appropriate regulatory agency or respirator supplier, whichever is lowest. For emergencies or instances where the exposure levels are not known, use a full-face piece positive-pressure, air-supplied respirator. WARNING: Air-purifying respirators do not protect workers in oxygen-deficient atmospheres. Supplied air is preferable when heat is involved.
Skin Protection:
Wear impervious protective clothing, including boots, gloves, lab coat, apron or coveralls, as appropriate, to prevent skin contact.
Eye Protection:
Use chemical safety goggles and/or full face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.

9. Physical and Chemical Properties

Appearance:
Pale pink crystals.
Odor:
No information found.
Solubility:
Freely soluble.
Specific Gravity:
No information found.
pH:
No information found.
% Volatiles by volume @ 21C (70F):
0
Boiling Point:
No information found.
Melting Point:
> 200C (> 392F)
Vapor Density (Air=1):
No information found.
Vapor Pressure (mm Hg):
No information found.
Evaporation Rate (BuAc=1):
No information found.

10. Stability and Reactivity

Stability:
Stable under ordinary conditions of use and storage.
Hazardous Decomposition Products:
May produce carbon monoxide, carbon dioxide, nitrogen oxides and hydrogen chloride when heated to decomposition.
Hazardous Polymerization:
Will not occur.
Incompatibilities:
Strong oxidizers.
Conditions to Avoid:
Incompatibles.

11. Toxicological Information

Toxicological Data:
Oral rat LD50: 147 mg/kg Investigated as a tumorigen and mutagen.
Carcinogenicity:
IARC Cancer Review:Animal Inadequate Evidence
 
  --------\Cancer Lists\------------------------------------------------------
                                         ---NTP Carcinogen---
  Ingredient                             Known    Anticipated    IARC Category
  ------------------------------------   -----    -----------    -------------
  p-Phenylenediamine Dihydrochloride      No          No            None
  (624-18-0)

12. Ecological Information

Environmental Fate:
No information found.
Environmental Toxicity:
No information found.

13. Disposal Considerations

Whatever cannot be saved for recovery or recycling should be managed in an appropriate and approved waste disposal facility. Processing, use or contamination of this product may change the waste management options. State and local disposal regulations may differ from federal disposal regulations. Dispose of container and unused contents in accordance with federal, state and local requirements.

14. Transport Information

Not regulated.

15. Regulatory Information

 
  --------\Chemical Inventory Status - Part 1\---------------------------------
  Ingredient                                       TSCA  EC   Japan  Australia
  -----------------------------------------------  ----  ---  -----  ---------
  p-Phenylenediamine Dihydrochloride (624-18-0)     Yes  Yes   Yes      Yes
 
  --------\Chemical Inventory Status - Part 2\---------------------------------
                                                          --Canada--
  Ingredient                                       Korea  DSL   NDSL  Phil.
  -----------------------------------------------  -----  ---   ----  -----
  p-Phenylenediamine Dihydrochloride (624-18-0)     Yes   Yes   No     Yes
 
  --------\Federal, State & International Regulations - Part 1\----------------
                                             -SARA 302-    ------SARA 313------
  Ingredient                                 RQ    TPQ     List  Chemical Catg.
  -----------------------------------------  ---   -----   ----  --------------
  p-Phenylenediamine Dihydrochloride         No    No      Yes        No
  (624-18-0)
 
  --------\Federal, State & International Regulations - Part 2\----------------
                                                        -RCRA-    -TSCA-
  Ingredient                                 CERCLA     261.33     8(d)
  -----------------------------------------  ------     ------    ------
  p-Phenylenediamine Dihydrochloride         No         No         No
  (624-18-0)
 
 
Chemical Weapons Convention:  No     TSCA 12(b):  No     CDTA:  No
SARA 311/312:  Acute: Yes      Chronic: Yes  Fire: No  Pressure: No
Reactivity: No          (Pure / Solid)


Australian Hazchem Code: 2X
Poison Schedule: None allocated.
WHMIS:
This MSDS has been prepared according to the hazard criteria of the Controlled Products Regulations (CPR) and the MSDS contains all of the information required by the CPR.

16. Other Information

NFPA Ratings: Health: 2 Flammability: 0 Reactivity: 0
Label Hazard Warning:
WARNING! HARMFUL IF SWALLOWED, INHALED OR ABSORBED THROUGH SKIN. CAUSES IRRITATION TO SKIN, EYES AND RESPIRATORY TRACT. MAY CAUSE ALLERGIC SKIN OR RESPIRATORY REACTION. MAY CAUSE KIDNEY, LIVER AND BLOOD DISORDERS.
Label Precautions:
Do not breathe dust.
Avoid contact with eyes, skin and clothing.
Avoid prolonged or repeated contact with skin.
Keep container closed.
Use with adequate ventilation.
Wash thoroughly after handling.
Label First Aid:
If swallowed, induce vomiting immediately as directed by medical personnel. Never give anything by mouth to an unconscious person. In case of contact, immediately flush eyes or skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Get medical attention. If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention.
Product Use:
Laboratory Reagent.
Revision Information:
No changes.
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Prepared by: Environmental Health & Safety
Phone Number: (314) 654-1600 (U.S.A.)