MSDS Number: T1833 * * * * * Effective Date: 02/10/09 * * * * * Supercedes: 05/24/06 Tetramethylammonium Hydroxide, 5-Hydrate


Tetramethylammonium Hydroxide, 5-Hydrate


1. Product Identification

Synonyms: Tetramethylammonium Hydroxide, Pentahydrate; TMAH
CAS No.: 75-59-2 (Anhydrous) 10424-65-4 (Pentahydrate)
Molecular Weight: 181.23
Chemical Formula: (CH3)4NOH . 5H2O
Product Codes: V642

2. Composition/Information on Ingredients


 
  Ingredient                                CAS No         Percent        Hazardous                                  
  ---------------------------------------   ------------   ------------   ---------   
 
  Tetramethylammonium Hydroxide             75-59-2          90 - 100%       Yes                                                                    
 

3. Hazards Identification

Emergency Overview
--------------------------
POISON! DANGER! CORROSIVE. CAUSES BURNS TO ANY AREA OF CONTACT. MAY BE FATAL IF SWALLOWED, INHALED OR ABSORBED THROUGH SKIN.

SAF-T-DATA(tm) Ratings (Provided here for your convenience)
-----------------------------------------------------------------------------------------------------------
Health Rating: 4 - Extreme (Poison)
Flammability Rating: 1 - Slight
Reactivity Rating: 1 - Slight
Contact Rating: 4 - Extreme (Corrosive)
Lab Protective Equip: GOGGLES & SHIELD; LAB COAT & APRON; VENT HOOD; PROPER GLOVES
Storage Color Code: White (Corrosive)
-----------------------------------------------------------------------------------------------------------

Potential Health Effects
----------------------------------

Exposure may result in intense burning of the eyes, nose, throat, lungs and skin. Experimental studies have indicated that TMAH is a weak inhibitor of acetylcholinesterase and acts as a cholinergic (muscarinic and nicotinic) agonist. Depending on the level and duration of exposure, signs and symptoms may include blurred or double vision; pinpoint pupils; changes in heart rate and blood pressure; abdominal cramping, nausea and vomiting; diarrhea, excessive salivation sweating or bronchial secretions; urinary incontinence; muscle twitching, tremors or convulsions. Other symptoms consistent with cholinergic activity may also be observed.

Inhalation:
Inhalation of alkaline vapors can produce upper airway edema, respiratory failure, wheezing, pulmonary edema, and pnemonitis.
Ingestion:
Alkaline corrosive ingestion may produce burns to the lips, tongue, oral mucosa, upper airway, esophagus and occasionally stomach.
Skin Contact:
Dermal contact with alkaline corrosives may produce pain, redness, severe irritation or full thickness burns. May be absorbed through the skin with possible systemic effects.
Eye Contact:
Alkaline eye exposures produce severe irritation with effects similar to those of dilute caustics. Inflammation or burns with possible damage to the eye tissues can occur together with tearing and considerable pain.
Chronic Exposure:
No information found.
Aggravation of Pre-existing Conditions:
Persons with pre-existing skin disorders or eye problems or impaired respiratory function may be more susceptible to the effects of the substance.

4. First Aid Measures

Inhalation:
Remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention immediately.
Ingestion:
If swallowed, DO NOT INDUCE VOMITING. Give large quantities of water. Never give anything by mouth to an unconscious person. Get medical attention immediately.
Skin Contact:
Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Get medical attention immediately. Wash clothing before reuse. Thoroughly clean shoes before reuse.
Eye Contact:
Immediately flush eyes with plenty of water for at least 15 minutes, lifting lower and upper eyelids occasionally. Get medical attention immediately.

5. Fire Fighting Measures

Fire:
Not considered to be a fire hazard.
Explosion:
Not considered to be an explosion hazard.
Fire Extinguishing Media:
Use any means suitable for extinguishing surrounding fire.
Special Information:
In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full facepiece operated in the pressure demand or other positive pressure mode.

6. Accidental Release Measures

Ventilate area of leak or spill. Keep unnecessary and unprotected people away from area of spill. Wear appropriate personal protective equipment as specified in Section 8. Do not flush caustic residues to the sewer. Residues from spills can be diluted with water, neutralized with dilute acid such as acetic, hydrochloric or sulfuric. Absorb neutralized caustic residue on clay, vermiculite or other inert substance and package in a suitable container for disposal.




7. Handling and Storage

Refrigeration required. Keep in a tightly closed container. Store in a cool, dry, corrosion-proof, ventilated area away from moisture, sources of heat or ignition, combustibles and oxidizers. Protect against physical damage. Containers of this material may be hazardous when empty since they retain product residues (dust, solids); observe all warnings and precautions listed for the product.

8. Exposure Controls/Personal Protection

Airborne Exposure Limits:
None established.
Ventilation System:
A system of local and/or general exhaust is recommended to keep employee exposures as low as possible. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area. Please refer to the ACGIH document, Industrial Ventilation, A Manual of Recommended Practices, most recent edition, for details.
Personal Respirators (NIOSH Approved):
For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator (NIOSH type N95 or better filters) may be worn. If oil particles (e.g. lubricants, cutting fluids, glycerine, etc.) are present, use a NIOSH type R or P filter. For emergencies or instances where the exposure levels are not known, use a full-face positive-pressure, air-supplied respirator. WARNING: Air-purifying respirators do not protect workers in oxygen-deficient atmospheres.
Skin Protection:
Wear impervious protective clothing, including boots, gloves, lab coat, apron or coveralls, as appropriate, to prevent skin contact.
Eye Protection:
Use chemical safety goggles and/or full face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.

9. Physical and Chemical Properties

Appearance:
White Crystalline solid.
Odor:
Strong ammonia-like odor.
Solubility:
70g/100 cc water @ 20C
Specific Gravity:
ca. 1.00 @ 25C/4C
pH:
> 13
% Volatiles by volume @ 21C (70F):
0
Boiling Point:
Unknown
Melting Point:
68 - 70C (154 - 158F)
Vapor Density (Air=1):
Not applicable.
Vapor Pressure (mm Hg):
Not applicable.
Evaporation Rate (BuAc=1):
Not applicable.

10. Stability and Reactivity

Stability:
Stable under ordinary conditions of use and storage. Readily absorbs CO2 from the air.
Hazardous Decomposition Products:
Ammonia, volatile amines, nitrogen oxides, and alcohols.
Hazardous Polymerization:
Will not occur.
Incompatibilities:
Strong acids and strong oxidizers.
Conditions to Avoid:
Heat, flames, ignition sources and incompatibles.

11. Toxicological Information


Skin guinea pig LD50 = 25 mg/kg Preliminary results from an experimental study in rats demonstrated lethality following one or more skin applications of tetramethylammonium hydroxide at dose levels of 30 mg/kg and higher.
 
  --------\Cancer Lists\------------------------------------------------------
                                         ---NTP Carcinogen---
  Ingredient                             Known    Anticipated    IARC Category
  ------------------------------------   -----    -----------    -------------
  Tetramethylammonium Hydroxide           No          No            None
  (75-59-2)

12. Ecological Information

Environmental Fate:
If neutralized, this material may be biodegradable. No specific information available.
Environmental Toxicity:
Acute aquatic toxicity testing on a pH neutralized solution of this compound has been shown to be highly toxic to the ceriodaphnia dubia (water flea).

13. Disposal Considerations

Whatever cannot be saved for recovery or recycling should be handled as hazardous waste and sent to a RCRA approved waste facility. Processing, use or contamination of this product may change the waste management options. State and local disposal regulations may differ from federal disposal regulations. Dispose of container and unused contents in accordance with federal, state and local requirements.

14. Transport Information

Domestic (Land, D.O.T.)
-----------------------
Proper Shipping Name: TETRAMETHYLAMMONIUM HYDROXIDE, SOLID
Hazard Class: 8
UN/NA: UN3423
Packing Group: II
Information reported for product/size: 1KG

International (Water, I.M.O.)
-----------------------------
Proper Shipping Name: TETRAMETHYLAMMONIUM HYDROXIDE, SOLID
Hazard Class: 8
UN/NA: UN3423
Packing Group: II
Information reported for product/size: 1KG

International (Air, I.C.A.O.)
-----------------------------
Proper Shipping Name: TETRAMETHYLAMMONIUM HYDROXIDE, SOLID
Hazard Class: 8
UN/NA: UN3423
Packing Group: II
Information reported for product/size: 1KG

15. Regulatory Information

 
  --------\Chemical Inventory Status - Part 1\---------------------------------
  Ingredient                                       TSCA  EC   Japan  Australia
  -----------------------------------------------  ----  ---  -----  ---------
  Tetramethylammonium Hydroxide (75-59-2)           Yes  Yes   Yes      Yes                                      
 
  --------\Chemical Inventory Status - Part 2\---------------------------------
                                                          --Canada--
  Ingredient                                       Korea  DSL   NDSL  Phil.
  -----------------------------------------------  -----  ---   ----  -----
  Tetramethylammonium Hydroxide (75-59-2)           Yes   Yes   No     Yes                    
 
  --------\Federal, State & International Regulations - Part 1\----------------
                                             -SARA 302-    ------SARA 313------
  Ingredient                                 RQ    TPQ     List  Chemical Catg.
  -----------------------------------------  ---   -----   ----  --------------
  Tetramethylammonium Hydroxide (75-59-2)    No    No      No         No
 
  --------\Federal, State & International Regulations - Part 2\----------------
                                                        -RCRA-    -TSCA-
  Ingredient                                 CERCLA     261.33     8(d) 
  -----------------------------------------  ------     ------    ------
  Tetramethylammonium Hydroxide (75-59-2)    No         No         No                  
 
 
Chemical Weapons Convention:  No     TSCA 12(b):  No     CDTA:  No
SARA 311/312:  Acute: Yes      Chronic: No   Fire: No  Pressure: No
Reactivity: No          (Pure / Solid) 


Australian Hazchem Code: 2R
Poison Schedule: None allocated.
WHMIS:
This MSDS has been prepared according to the hazard criteria of the Controlled Products Regulations (CPR) and the MSDS contains all of the information required by the CPR.

16. Other Information

NFPA Ratings: Health: 3 Flammability: 0 Reactivity: 0
Label Hazard Warning:
POISON! DANGER! CORROSIVE. CAUSES BURNS TO ANY AREA OF CONTACT. MAY BE FATAL IF SWALLOWED, INHALED OR ABSORBED THROUGH SKIN.
Label Precautions:
Do not breathe dust.
Do not get in eyes, on skin, or on clothing.
Keep container closed.
Use only with adequate ventilation.
Wash thoroughly after handling.
Label First Aid:
In case of contact, immediately flush eyes or skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. If swallowed, DO NOT INDUCE VOMITING. Give large quantities of water. Never give anything by mouth to an unconscious person. In all cases get medical attention immediately.
Product Use:
Laboratory Reagent.
Revision Information:
No Changes.
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Prepared by: Environmental Health & Safety
Phone Number: (314) 654-1600 (U.S.A.)