MSDS Number: C0169 * * * * * Effective Date: 10/19/05 * * * * * Supercedes: 11/12/03 CAFFEINE CITRATED


1. Product Identification

Synonyms: 1 H-Purine-2,6-dione, 3, 7-dihydro-1,3,7-trimethyl-,and 2-hydroxy-1,2,3-propanetricarboxylate (1:1); Citric acid and caffeine mixture
CAS No.: 69-22-7
Molecular Weight: 386.32
Chemical Formula: C8H10N4O2.C6H8O7
Product Codes:
J.T. Baker: 1649
Mallinckrodt: 0646

2. Composition/Information on Ingredients

  Ingredient                                CAS No         Percent        Hazardous                                  
  ---------------------------------------   ------------   ------------   ---------   
  Caffeine                                  58-08-2             50%          Yes                                                                 
  Citric Acid                               77-92-9             50%          Yes                                                                 

3. Hazards Identification

Emergency Overview

SAF-T-DATA(tm) Ratings (Provided here for your convenience)
Health Rating: 2 - Moderate
Flammability Rating: 1 - Slight
Reactivity Rating: 0 - None
Contact Rating: 1 - Slight
Storage Color Code: Green (General Storage)

Potential Health Effects

The effects are not expected to be as severe as exposure to pure caffeine which may have the symptoms of a mild irritant to the respiratory tract. May be a route of absorption by the body.
May cause central nervous system stimulation. The effects are not expected to be as severe as exposure to large doses of pure caffeine (5-10 grams) which may have the symptoms of wakefulness, nausea, ringing in the ears, and mild excitement. Large doses may cause palpitations, or convulsions, and gastric irritation.
Skin Contact:
No adverse effects expected.
Eye Contact:
May cause mechanical irritation.
Chronic Exposure:
Caffeine is extensively metabolized by man. Effects from chronic exposure are not fully understood.
Aggravation of Pre-existing Conditions:
No information found.

4. First Aid Measures

Remove to fresh air. Get medical attention for any breathing difficulty.
Induce vomiting immediately as directed by medical personnel. Never give anything by mouth to an unconscious person.
Skin Contact:
Wash exposed area with soap and water. Get medical advice if irritation develops.
Eye Contact:
Wash thoroughly with running water. Get medical advice if irritation develops.

5. Fire Fighting Measures

As with most organic solids, fire is possible at elevated temperatures or by contact with an ignition source.
Fine dust dispersed in air in sufficient concentrations, and in the presence of an ignition source is a potential dust explosion hazard.
Fire Extinguishing Media:
Water spray, carbon dioxide, or dry powder.
Special Information:
In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full facepiece operated in the pressure demand or other positive pressure mode.

6. Accidental Release Measures

Remove all sources of ignition. Ventilate area of leak or spill. Wear appropriate personal protective equipment as specified in Section 8. Spills: Clean up spills in a manner that does not disperse dust into the air. Use non-sparking tools and equipment. Reduce airborne dust and prevent scattering by moistening with water. Pick up spill for recovery or disposal and place in a closed container.

7. Handling and Storage

Keep in a tightly closed container, stored in a cool, dry, ventilated area. Protect against physical damage. Isolate from any source of heat or ignition. Containers of this material may be hazardous when empty since they retain product residues (dust, solids); observe all warnings and precautions listed for the product.

8. Exposure Controls/Personal Protection

Airborne Exposure Limits:
None established.
Ventilation System:
A system of local and/or general exhaust is recommended to keep employee exposures as low as possible. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area. Please refer to the ACGIH document, Industrial Ventilation, A Manual of Recommended Practices, most recent edition, for details.
Personal Respirators (NIOSH Approved):
For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator (NIOSH type N95 or better filters) may be worn. If oil particles (e.g. lubricants, cutting fluids, glycerine, etc.) are present, use a NIOSH type R or P filter. For emergencies or instances where the exposure levels are not known, use a full-face positive-pressure, air-supplied respirator. WARNING: Air-purifying respirators do not protect workers in oxygen-deficient atmospheres.
Skin Protection:
Wear protective gloves and clean body-covering clothing.
Eye Protection:
Use chemical safety goggles. Maintain eye wash fountain and quick-drench facilities in work area.

9. Physical and Chemical Properties

White powder.
Soluble in about four parts warm water, decomposes and redissolves.
Specific Gravity:
1.41 (weighted average).
% Volatiles by volume @ 21C (70F):
No information found.
Boiling Point:
No information found.
Melting Point:
238C Based on data for caffeine. Weighted average: 195.5C
Vapor Density (Air=1):
No information found.
Vapor Pressure (mm Hg):
No information found.
Evaporation Rate (BuAc=1):
No information found.

10. Stability and Reactivity

Stable under ordinary conditions of use and storage.
Hazardous Decomposition Products:
Burning may produce carbon monoxide, carbon dioxide, nitrogen oxides.
Hazardous Polymerization:
Will not occur.
Reactive with oxidizing agents, alkalis.

Citric Acid Component:
Metal nitrates (potentially explosive reaction), alkali carbonates and bicarbonates, potassium tartrate. Will corrode copper, zinc, aluminum and their alloys.
Conditions to Avoid:
No information found.

11. Toxicological Information

Caffeine: Oral rat LD50: 192 mg/kg Mutation data references cited. Reproductive effects references cited.
  --------\Cancer Lists\------------------------------------------------------
                                         ---NTP Carcinogen---
  Ingredient                             Known    Anticipated    IARC Category
  ------------------------------------   -----    -----------    -------------
  Caffeine (58-08-2)                      No          No              3
  Citric Acid (77-92-9)                   No          No            None

12. Ecological Information

Environmental Fate:
No information found.
Environmental Toxicity:
No information found.

13. Disposal Considerations

Whatever cannot be saved for recovery or recycling should be managed in an appropriate and approved waste disposal facility. Processing, use or contamination of this product may change the waste management options. State and local disposal regulations may differ from federal disposal regulations. Dispose of container and unused contents in accordance with federal, state and local requirements.

14. Transport Information

Not regulated.

15. Regulatory Information

  --------\Chemical Inventory Status - Part 1\---------------------------------
  Ingredient                                       TSCA  EC   Japan  Australia
  -----------------------------------------------  ----  ---  -----  ---------
  Caffeine (58-08-2)                                Yes  Yes   Yes      Yes                                      
  Citric Acid (77-92-9)                             Yes  Yes   Yes      Yes                                      
  --------\Chemical Inventory Status - Part 2\---------------------------------
  Ingredient                                       Korea  DSL   NDSL  Phil.
  -----------------------------------------------  -----  ---   ----  -----
  Caffeine (58-08-2)                                Yes   Yes   No     Yes
  Citric Acid (77-92-9)                             Yes   Yes   No     Yes  
  --------\Federal, State & International Regulations - Part 1\----------------
                                             -SARA 302-    ------SARA 313------
  Ingredient                                 RQ    TPQ     List  Chemical Catg.
  -----------------------------------------  ---   -----   ----  --------------
  Caffeine (58-08-2)                         No    No      No         No
  Citric Acid (77-92-9)                      No    No      No         No
  --------\Federal, State & International Regulations - Part 2\----------------
                                                        -RCRA-    -TSCA-
  Ingredient                                 CERCLA     261.33     8(d) 
  -----------------------------------------  ------     ------    ------
  Caffeine (58-08-2)                         No         No         No                                                                 
  Citric Acid (77-92-9)                      No         No         No
Chemical Weapons Convention:  No     TSCA 12(b):  No     CDTA:  No
SARA 311/312:  Acute: Yes      Chronic: No   Fire: No  Pressure: No
Reactivity: No          (Mixture / Solid)

Australian Hazchem Code: None allocated.
Poison Schedule: None allocated.
This MSDS has been prepared according to the hazard criteria of the Controlled Products Regulations (CPR) and the MSDS contains all of the information required by the CPR.

16. Other Information

NFPA Ratings: Health: 2 Flammability: 1 Reactivity: 0
Label Hazard Warning:
Label Precautions:
Wash thoroughly after handling.
Label First Aid:
If swallowed, induce vomiting immediately as directed by medical personnel. Never give anything by mouth to an unconscious person. Call a physician.
Product Use:
Laboratory Reagent.
Revision Information:
MSDS Section(s) changed since last revision of document include: 3.
Prepared by: Environmental Health & Safety
Phone Number: (314) 654-1600 (U.S.A.)