Histamine Dihydrochloride MSDS

Section 1: Chemical Product and Company Identification

Product Name: Histamine Dihydrochloride

Catalog Codes: SLH2416

CAS#: 56-92-8

RTECS: MS1575000

TSCA: TSCA 8(b) inventory: Histamine Dihydrochloride

CI#: Not available.

Synonym: Histamine Dichloride;

1H-Imidazole-4-ethanamine hydrochloride

Chemical Name: Histamine Dihydrochloride

Chemical Formula: C5-H9-N3.HCl

Section 2: Composition and Information on Ingredients

Composition:

Name CAS # % by Weight

Histamine Dihydrochloride 56-92-8 100

Toxicological Data on Ingredients: Not applicable.

Section 3: Hazards Identification

Potential Acute Health Effects:

Slightly hazardous in case of skin contact (irritant, sensitizer), of eye contact (irritant), of ingestion, of inhalation

(lung sensitizer).

Potential Chronic Health Effects:

CARCINOGENIC EFFECTS: Not available.

MUTAGENIC EFFECTS: Not available.

TERATOGENIC EFFECTS: Not available.

DEVELOPMENTAL TOXICITY: Not available.

The substance may be toxic to Smooth Muscle.

Repeated or prolonged exposure to the substance can produce target organs damage.

Section 4: First Aid Measures

Eye Contact:

Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at

least 15 minutes. Cold water may be used. Get medical attention if irritation occurs.

Skin Contact:

Wash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation develops.

Cold water may be used.

Serious Skin Contact: Not available.

Inhalation:

If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get

medical attention.

Serious Inhalation: Not available.

Ingestion:

Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an

unconscious person. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical attention if

symptoms appear.

Serious Ingestion: Not available.

Section 5: Fire and Explosion Data

Flammability of the Product: May be combustible at high temperature.

Auto-Ignition Temperature: Not available.

Flash Points: Not available.

Flammable Limits: Not available.

Products of Combustion: These products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...).

Fire Hazards in Presence of Various Substances:

Slightly flammable to flammable in presence of heat.

Non-flammable in presence of oxidizing materials.

Explosion Hazards in Presence of Various Substances:

Risks of explosion of the product in presence of mechanical impact: Not available.

Slightly explosive in presence of open flames and sparks.

Non-explosive in presence of heat.

Fire Fighting Media and Instructions:

SMALL FIRE: Use DRY chemical powder.

LARGE FIRE: Use water spray, fog or foam. Do not use water jet.

Special Remarks on Fire Hazards: As with most organic solids, fire is possible at elevated temperatures

Special Remarks on Explosion Hazards:

Fine dust dispersed in air in sufficient concentrations, and in the presences of an ignition source is a potential dust

explosion hazard.

Section 6: Accidental Release Measures

Small Spill:

Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by

spreading water on the contaminated surface and dispose of according to local and regional authority

requirements.

Large Spill:

Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water

on the contaminated surface and allow to evacuate through the sanitary system.

Section 7: Handling and Storage

Precautions:

Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do not

ingest. Do not breathe dust. If ingested, seek medical advice immediately and show the container or the label.

Keep away from incompatibles such as oxidizing agents.

Storage:

Keep container tightly closed. Keep container in a cool, well-ventilated area. Do not store above 8°C (46.4°F).

Refrigerate.

Section 8: Exposure Controls/Personal Protection

Engineering Controls:

Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below

recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to

airborne contaminants below the exposure limit.

Personal Protection: Safety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent.

Gloves.

Personal Protection in Case of a Large Spill:

Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used

to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist

BEFORE handling this product.

Exposure Limits: Not available.

Section 9: Physical and Chemical Properties

Physical state and appearance: Solid. (Crystals solid. Crystalline powder.)

Odor: Not available.

Taste: Not available.

Molecular Weight: 184.07 g/mole

Color: White.

pH (1% soln/water): Not available.

Boiling Point: Not available.

Melting Point: 244°C (471.2°F) - 246 C

Critical Temperature: Not available.

Specific Gravity: Not available.

Vapor Pressure: Not applicable.

Vapor Density: Not available.

Volatility: Not available.

Odor Threshold: Not available.

Water/Oil Dist. Coeff.: Not available.

Ionicity (in Water): Not available.

Dispersion Properties: See solubility in water, methanol.

Solubility: Easily soluble in cold water, hot water, methanol.

Section 10: Stability and Reactivity Data

Stability: The product is stable.

Instability Temperature: Not available.

Conditions of Instability: Excess heat, incompatible materials

Incompatibility with various substances: Reactive with oxidizing agents.

Corrosivity: Not available.

Special Remarks on Reactivity: Not available.

Special Remarks on Corrosivity: Not available.

Polymerization: Will not occur.

Section 11: Toxicological Information

Routes of Entry: Inhalation. Ingestion.

Toxicity to Animals: Acute oral toxicity (LD50): 2534 mg/kg [Mouse].

Chronic Effects on Humans: May cause damage to the following organs: Smooth Muscle.

Other Toxic Effects on Humans: Slightly hazardous in case of skin contact (irritant, sensitizer), of ingestion, of inhalation

(lung sensitizer).

Special Remarks on Toxicity to Animals: Not available.

Special Remarks on Chronic Effects on Humans: May cause adverse reproductive effects and birth defects (teratogenic)

Special Remarks on other Toxic Effects on Humans:

Acute Potential Health Effects:

Skin: May cause skin irritation. May cause allergic skin reaction. May cause sensitization by skin contact.

Eyes: May cause eye irritation.

Inhalation: May cause respiratory tract irritation. May cause allergic respiratory reaction.

Ingestion: May cause gastrointestinal tract irritation with nausea, vomiting and diarrhea. May affect

behavior/central nervous system, respiration, and cardiovascular system. Symptoms may include sommolence,

rigidity, temor, dizziness, fainting, headache, rapid weak pulse, pain, flushing, pallor, fall in blood pressure,

bronchiolar constriction, dyspnea, cyanosis.

Section 12: Ecological Information

Ecotoxicity: Not available.

BOD5 and COD: Not available.

Products of Biodegradation:

Possibly hazardous short term degradation products are not likely. However, long term degradation products may

arise.

Toxicity of the Products of Biodegradation: The product itself and its products of degradation are not toxic.

Special Remarks on the Products of Biodegradation: Not available.

Section 13: Disposal Considerations

Waste Disposal:

Waste must be disposed of in accordance with federal, state and local environmental

control regulations.

Section 14: Transport Information

DOT Classification: Not a DOT controlled material (United States).

Identification: Not applicable.

Special Provisions for Transport: Not applicable.

Section 15: Other Regulatory Information

Federal and State Regulations: TSCA 8(b) inventory: Histamine Dihydrochloride

Other Regulations: EINECS: This product is on the European Inventory of Existing Commercial Chemical Substances.

Other Classifications:

WHMIS (Canada): Not controlled under WHMIS (Canada).

DSCL (EEC):

This product is not classified according

to the EU regulations.

S24/25- Avoid contact with skin and eyes.

S36/37/39- Wear suitable protective clothing,

gloves and eye/face protection.

HMIS (U.S.A.):

Health Hazard: 1

Fire Hazard: 1

Reactivity: 0

Personal Protection: E

National Fire Protection Association (U.S.A.):

Health: 1

Flammability: 1

Reactivity: 0

Specific hazard:

Protective Equipment:

Gloves.

Lab coat.

Dust respirator. Be sure to use an

approved/certified respirator or

equivalent.

Safety glasses.

Section 16: Other Information

References: Not available.

Other Special Considerations: Not available.

Created: 10/09/2005 05:44 PM

Last Updated: 11/06/2008 12:00 PM