Hyoscyamine Hydrobromide MSDS

Section 1: Chemical Product and Company Identification

Product Name: Hyoscyamine Hydrobromide

Catalog Codes: SLH1870

CAS#: 306-03-6

RTECS: Not available.

TSCA: TSCA 8(b) inventory: Hyoscyamine Hydrobromide

CI#: Not available.

Synonym: L-Hyoscyamine hydrobromide;

[3(S)-endo-alpha-(Hydroxymeethy)benzeneacetic acid

8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester hydrobromide

Chemical Name: Hyoscyamine Hydrobromide

Chemical Formula: C17-H23-O3-N.HBr

Section 2: Composition and Information on Ingredients

Composition:

Name CAS # % by Weight

Hyoscyamine Hydrobromide 306-03-6 100

Toxicological Data on Ingredients: Hyoscyamine Hydrobromide LD50: Not available. LC50: Not available.

Section 3: Hazards Identification

Potential Acute Health Effects:

Very hazardous in case of ingestion. Hazardous in case of skin contact (irritant), of eye contact (irritant), of

inhalation. Severe over-exposure can result in death.

Potential Chronic Health Effects:

CARCINOGENIC EFFECTS: Not available.

MUTAGENIC EFFECTS: Not available.

TERATOGENIC EFFECTS: Not available.

DEVELOPMENTAL TOXICITY: Not available.

The substance may be toxic to central nervous system (CNS).

Repeated or prolonged exposure to the substance can produce target organs damage. Repeated exposure to a

highly toxic material may produce general deterioration of health by an accumulation in one or many human

organs.

Section 4: First Aid Measures

Eye Contact:

Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at

least 15 minutes. Get medical attention.

Skin Contact:

In case of contact, immediately flush skin with plenty of water for at least 15 minutes while removing contaminated

clothing and shoes. Cover the irritated skin with an emollient. Wash clothing before reuse. Thoroughly clean

shoes before reuse. Get medical attention immediately.

Serious Skin Contact:

Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek immediate

medical attention.

Inhalation:

If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get

medical attention immediately.

Serious Inhalation:

Evacuate the victim to a safe area as soon as possible. Loosen tight clothing such as a collar, tie, belt or

waistband. If breathing is difficult, administer oxygen. If the victim is not breathing, perform mouth-to-mouth

resuscitation. WARNING: It may be hazardous to the person providing aid to give mouth-to-mouth resuscitation

when the inhaled material is toxic, infectious or corrosive. Seek immediate medical attention.

Ingestion:

If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by

mouth to an unconscious person. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical

attention immediately.

Serious Ingestion: Not available.

Section 5: Fire and Explosion Data

Flammability of the Product: May be combustible at high temperature.

Auto-Ignition Temperature: Not available.

Flash Points: Not available.

Flammable Limits: Not available.

Products of Combustion: These products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...).

Fire Hazards in Presence of Various Substances:

Slightly flammable to flammable in presence of heat.

Non-flammable in presence of shocks.

Explosion Hazards in Presence of Various Substances:

Slightly explosive in presence of open flames and sparks.

Non-explosive in presence of shocks.

Fire Fighting Media and Instructions:

SMALL FIRE: Use DRY chemical powder.

LARGE FIRE: Use water spray, fog or foam. Do not use water jet.

Special Remarks on Fire Hazards: As with most organic solids, fire is possible at elevated temperatures

Special Remarks on Explosion Hazards:

Fine dust dispersed in air in sufficient concentrations, and in the presences of an ignition source is a potential dust

explosion hazard.

Section 6: Accidental Release Measures

Small Spill: Use appropriate tools to put the spilled solid in a convenient waste disposal container.

Large Spill:

Poisonous solid.

Stop leak if without risk. Do not get water inside container. Do not touch spilled material. Use water spray to

reduce vapors. Prevent entry into sewers, basements or confined areas; dike if needed. Eliminate all ignition

sources. Call for assistance on disposal.

Section 7: Handling and Storage

Precautions:

Keep away from heat. Keep away from sources of ignition. Do not ingest. Do not breathe dust. Wear suitable

protective clothing. In case of insufficient ventilation, wear suitable respiratory equipment. If ingested, seek

medical advice immediately and show the container or the label. Avoid contact with skin and eyes.

Storage:

Keep container tightly closed. Keep container in a cool, well-ventilated area. Do not store above 8°C (46.4°F).

Refrigerate Sensitive to light. Store in light-resistant containers.

Section 8: Exposure Controls/Personal Protection

Engineering Controls:

Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below

recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to

airborne contaminants below the exposure limit.

Personal Protection:

Splash goggles. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent.

Gloves.

Personal Protection in Case of a Large Spill:

Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used

to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist

BEFORE handling this product.

Exposure Limits: Not available.

Section 9: Physical and Chemical Properties

Physical state and appearance: Solid. (Powdered solid.)

Odor: Slight.

Taste: Not available.

Molecular Weight: 370.28 g/mole

Color: White.

pH (1% soln/water): Not available.

Boiling Point: Not available.

Melting Point: 149°C (300.2°F)

Critical Temperature: Not available.

Specific Gravity: Bulk Density: 400 kg/m3

Vapor Pressure: Not applicable.

Vapor Density: Not available.

Volatility: Not available.

Odor Threshold: Not available.

Water/Oil Dist. Coeff.: Not available.

Ionicity (in Water): Not available.

Dispersion Properties: Not available.

Solubility: Not available.

Section 10: Stability and Reactivity Data

Stability: The product is stable.

Instability Temperature: Not available.

Conditions of Instability: Excess heat, dust generation, light

Incompatibility with various substances: Not available.

Corrosivity: Not available.

Special Remarks on Reactivity: Sensitive to light.

Special Remarks on Corrosivity: Not available.

Polymerization: Will not occur.

Section 11: Toxicological Information

Routes of Entry: Inhalation. Ingestion.

Toxicity to Animals:

LD50: Not available.

LC50: Not available.

Chronic Effects on Humans: May cause damage to the following organs: central nervous system (CNS).

Other Toxic Effects on Humans:

Very hazardous in case of ingestion.

Hazardous in case of skin contact (irritant), of inhalation.

Special Remarks on Toxicity to Animals: Not available.

Special Remarks on Chronic Effects on Humans: Not available.

Special Remarks on other Toxic Effects on Humans:

Acute Potential Health Effects:

Skin: May cause skin irritation.

Eyes: May cause eye irritation.

Inhalation: May cause respiratory tract irritation.

Ingestion: Harmful if swallowed. May cause gastrointestinal tract irritation with abdominal distension, suppressed

salivation, dry and burning mouth, difficult swallowing, marked thirst. May affect behavior/central nervous system,

respiratory system (dyspnea), cardiovascular system, vision. An anticholinergic agent. It can cause blurred

visioin, photophobia, vasodilation, rapid and weak pulse, tachydardia, hyperpyrexia, excitement, muscular

incoordination, convulsions, agitation, restlessness, disturbed gait and speech, hallucinations, delirium, and pupil

dilation, bradycardia. Effects suggested by analogy to (-)-hyoscyamine

Section 12: Ecological Information

Ecotoxicity: Not available.

BOD5 and COD: Not available.

Products of Biodegradation:

Possibly hazardous short term degradation products are not likely. However, long term degradation products may

arise.

Toxicity of the Products of Biodegradation: The products of degradation are less toxic than the product itself.

Special Remarks on the Products of Biodegradation: Not available.

Section 13: Disposal Considerations

Waste Disposal:

Waste must be disposed of in accordance with federal, state and local environmental

control regulations.

Section 14: Transport Information

DOT Classification: CLASS 6.1: Poisonous material.

Identification: : Alkaloid solid, n.o.s.(Hyoscyamine Hydrobromide) UNNA: 1544 PG: III

Special Provisions for Transport: Not available.

Section 15: Other Regulatory Information

Federal and State Regulations: TSCA 8(b) inventory: Hyoscyamine Hydrobromide

Other Regulations:

OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200).

EINECS: This product is on the European Inventory of Existing Commercial Chemical Substances.

Other Classifications:

WHMIS (Canada): CLASS D-1B: Material causing immediate and serious toxic effects (TOXIC).

DSCL (EEC):

R26/28- Very toxic by inhalation and if

swallowed.

S24/25- Avoid contact with skin and eyes.

S36/37/39- Wear suitable protective clothing,

gloves and eye/face protection.

S45- In case of accident or if you feel unwell,

seek medical advice immediately (show the

label where possible).

HMIS (U.S.A.):

Health Hazard: 2

Fire Hazard: 1

Reactivity: 0

Personal Protection: E

National Fire Protection Association (U.S.A.):

Health: 2

Flammability: 1

Reactivity: 0

Specific hazard:

Protective Equipment:

Gloves.

Lab coat.

Dust respirator. Be sure to use an

approved/certified respirator or

equivalent. Wear appropriate respirator

when ventilation is inadequate.

Splash goggles.

Section 16: Other Information

References: Not available.

Other Special Considerations: Not available.

Created: 10/09/2005 05:48 PM

Last Updated: 11/06/2008 12:00 PM